Inflammatory and Autoimmune Disorders of the Nervous System in Children

by Dale, Russell C.; Vincent, Angela

• ISBN13: 9781898683667
• ISBN10: 1898683662
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-01-19
• Publisher: Mac Keith Press

Summary

This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. The book highlights some recent and exciting developments in the field, and will be of considerable importance to the pediatrician and pediatric neurologist. By helping to increase recognition of these conditions, this book will encourage further research into these diseases.

Author Biography

Russell C. Dale is a paediatric neurologist and researcher in inflammatory and autoimmune disorders of the central nervous system at Children’s Hospital at Westmead, University of Sydney, Australia. His main interests are inflammatory mechanisms, particularly novel auto-antibodies, in immune-mediated CNS disorders. He is part of the International Pediatric MS Study Group committee and has active research interests in paediatric CNS demyelination and autoimmune movement disorders. He has published in peer-reviewed journals including Nature Medicine, Lancet Neurology, Annals of Neurology, Brain, Neurology and Movement Disorders. Russell received the British Paediatric Neurology Association junior investigator award in 2003. He is an invited speaker at international conferences related to his interests in paediatric movement disorders and neuroinflammatory disorders. He appeared in the BBC documentary on ‘Encephalitis lethargica’ in 2004 and has been interviewed for a number of newspaper articles.

Angela Vincent is Emeritus Professor of Neuroimmunology in the University of Oxford and an Emeritus Fellow of Somerville College.  She was formerly head of the Department of Clinical Neurology and head of the Neurosciences Group at the Weatherall Institute of Molecular Medicine. She continues as an Honorary Consultant in Immunology and runs the clinical neuroimmunology service, an international referral centre for neurological antibodies. She collaborates with neurologists worldwide. She is best known for identifying new targets for autoantibodies in neuromuscular junction disorders and in non-paraneoplastic brain diseases, and for establishing diagnostic assays for these conditions. She has received several awards and honours (honorary PhD University of Bergen, honorary FRCP, FMedSci) and given many named lectures.  She is a past president of the International Society of Neuroimmunology and an Associate Editor of Brain.

Table of Contents

Neuroimmunology Concepts

Introduction and Overview

Inflammation and Autoimmunity: A Nervous System Perspective

Central Nervous System Disorders

Demyelinating Syndromes

Overview of New International Definitions For CNS Demyelination Syndromes in Children

Acute Disseminated Encephalomyelitis

Childhood Multiple Sclerosis

Multiple Sclerosis: An Adults Perspective

Transverse Myelitis

Optic Neuritis In Children

Regional Neuroinflammatory Syndromes Sydenham's Chorea

Paediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection (PANDAS)

Opsoclonus Myclonus Syndrome

Other Immune-Mediated Extrapyramidal Movement Disorders

Post-Infectious Ataxia and Cerebellitis

Rasmussen Encephalitis

Systemic Autoimmune Disorders and Vasculitis

Neuropsychiatric Manifestationsd of Childhood Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Cerebral Vasculitis

Macrophage Activation Syndromes

Orphan Neuro-Inflammatory Disorders Aicardi-Goutieres Syndrome and Related Disorders

Neonatal Onset Multisystemj Inflammatory Disorder (NOMID)/Chronic Infantile Neurological Cutaneous Syndrome (CINCA)

Folate Receptor Autoimmunity in Cerebral Folate Deficiency

Emerging Concepts Inflammatory Mechanisms in Neurodegenerative Disorders

Glutamate Receptor Autoantibodies in Neurological Syndromes

Autoimmune Channelopathies: Lessons From Adult Neurology

Peripheral Nervous System Disorders

Childhood Autoimmune Myasthenia

Guillain-Barre Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy in Childhood

Dermatomyositis and Polymyositis

Inflammatory Mechanisms in Genetic Neuromuscular Disorders

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