9781405157254

Inflammatory Bowel Disease : Translating Basic Science into Clinical Practice

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  • ISBN13:

    9781405157254

  • ISBN10:

    1405157259

  • Format: Hardcover
  • Copyright: 2010-05-24
  • Publisher: Wiley-Blackwell
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  • The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

Summary

This is the state-of-the-art book on inflammatory bowel disease you have been waiting forWritten and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD.In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine.This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

Author Biography

Stephan R. Targan, MD Director, Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute, and Division of Gastroenterology, Los Angeles, CA, USA
Fergus Shanahan, MD Professor and Chair, Department of Medicine and Director, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland; Professor, Department of Medicine, Cork University Hospital, Cork, Ireland
Loren c. Karp Researcher/Specialist, Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, CA, USA

Table of Contents

List of Contributors
Preface
Overview of inflammatory bowel diseases: from bench to bedside and back
Heterogeneity of inflammatory bowel diseases
Epidemiology: the changing faces of Crohn's disease and ulcerative colitis
Genetics of inflammatory bowel disease
Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanisms
The normal intestinal mucosa: a state of "controlled" inflammation
Innate immunity
Adaptive immunity (novel effector cells/TGF SMAD)
The bacterial/epithelial/lymphocyte interface
Cytokines and chemokines in mucosal homeostasis
Role of the microcirculation in chronic gut inflammation
Remission, relapse, intestinal healing and repair
Pathophysiology of inflammatory bowel disease: the bidirectional relationship of gut physiological systems and the mucosal immune system
Pathogenesis: systemic consequences of intestinal inflammation
Clinical course and complications of ulcerative colitis and ulcerative proctitis
Clinical features and complications of Crohn's disease
Practical IBD pathology in patient management
An endoscopist's perspective of diagnosis: when, where and what?
Imaging in inflammatory bowel disease: CT and MR enterography, ultrasound, and enteroscop
New diagnostic approaches integrating serologics endoscopy and radiology and genomics)
Differential diagnosis of colitis
Issues related to practice guidelines, reimbursement, drug rationing in the US and Europe
Pharmacoeconomic outcomes/disease activity indices/study design
Muti-site therapeutic modalities for inflammatory bowel diseases: mechanisms of action, combination therapy
Site specific therapeutics for inflammatory bowel diseases
Therapeutic manipulation of the microbiota in inflammatory bowel disease: antibiotics and probiotics
Nutrition and inflammatory bowel diseases
Medical management of ulcerative colitis
Surgical management of ulcerative colitis
Clinical characteristics and management of pouchitis and ileal pouch disorders
Medical management of Crohns disease
Surgical treatment of Crohns disease/perianal Crohns disease
Management of post-operative prevention of recurrence in Crohns disease
The molecular pathology of IBD-associated neoplasia and preneoplasia
Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance method
Hepatobiliary diseases in patients with inflammatory bowel diseases
Articular and ocular complications of inflammatory bowel diseases
Cutaneous manifestations of inflammatory bowel diseases
Fertility and pregnancy in inflammatory bowel diseases
Special considerations in pediatric inflammatory bowel diseases
Collagenous and lymphocytic colitis
IBD microcirculation and diversion, diverticular and other non-infectious colitides
Clostridium difficile associated diarrhea
Infectious colitis
Human immunodeficiency virus and inflammatory bowel diseases
Bone metabolism and inflammatory bowel disease
Comprehensive approach to patient risk: risks versus benefits of immunomodulators and biologic therapy for IBD
Complementary medicine
Legal pitfalls in treating IBD patients
The present and future of research and treatment of inflammatory bowel disease
Table of Contents provided by Publisher. All Rights Reserved.

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