The Innate Immune Response to Infection

by Kaufmann, Stefan H. E.; Medzhitov, Ruslan; Gordon, Siamon

• ISBN13: 9781555812911
• ISBN10: 1555812910
• Format: Hardcover
• Copyright: 2004-07-30
• Publisher: Amer Society for Microbiology

Summary

The Innate Immune Response to Infection delivers a timely, state-of-the-art review of the innate immune system, utilizing the most current concepts of cellular and molecular biology. Unique in its presentation, this new volume covers all aspects of innate immunity with an emphasis on response to infectious agents. It is a valuable reference source for scientists and students active in all areas of immunology and microbiology, as well as virology, parasitology, and infectious diseases. Written by experts in the field, the book focuses on evolutionary aspects, describing the major cells, humoral factors, and effector responses central to innate immunity and its important relation to acquired immunity. In-depth treatment is given to teh performance of the innate immune system in various situations, including bacterial, viral, fungal, and parasitic infection. Key Features: concentrates on an area of research that has reemerged to the forefront of immunology utilizes the

Table of Contents

Contributors	vii
Preface	xi
Evolutionary Emergence and Interactions among Elements of the Innate and Combinatorial Responses	1	(30)
John J. Marchalonis
G. Kerr Whitfield
Samuel F. Schluter
Drosophila Responses to Microbial Infection: an Overview	31	(16)
Jules A. Hoffmann
Petros Ligoxygakis
MAMMALIAN CELLS
Neutrophils: the Power Within	47	(24)
Taco W. Kuijpers
Dirk Roos
The Biology of Macrophages	71	(24)
R. Tedjo Sasmono
David A. Hume
The Regulatory Role of Dendritic Cells in the Innate Immune Response	95	(16)
F. Granucci
S. Feau
I. Zanoni
G. Raimondi
N. Pavelka
C. Vizzardelli
P. Ricciardi-Castagnoli
Roles of Mast Cells and Basophils in Innate Immunity	111	(22)
Stephen J. Galli
Devavani Chatterjea
Mindy Tsai
Innate Natural Killer Cell Responses to Infection	133	(24)
Wayne M. Yokoyama
Urinary Tract Infection as a Model for Innate Mucosal Immunity	157	(14)
M. Samuelsson
G. Bergsten
H. Fischer
D. Karpman
I. Leijonhufvud
A. C. Lundstedt
P. Samuelsson
M. L. Svensson
B. Wullt
C. Svanborg
Paneth Cells in Innate Immunity and Intestinal Inflammation	171	(28)
Satish Keshav
HUMORAL FACTORS
Collectins and the Acute-Phase Response	199	(20)
Howard Clark
Thilo Stehle
Alan Ezekowitz
Kenneth Reid
Complement and Its Receptors in Infection	219	(22)
Admar Verschoor
Michael C. Carroll
Coagulation and Innate Immunity	241	(16)
Charles T. Esmon
RECEPTORS
Toll-Like Receptors: Ligands and Signaling	257	(14)
Kiyoshi Takeda
Shizuo Akira
Toll-Like Receptors and Control of Adaptive Immunity	271	(16)
Gregory M. Barton
Chandrashekhar Pasare
Ruslan Medzhitov
Antigen-Presenting Cell Receptors and Innate Immunity: Diversity, Recognition, and Responses	287	(14)
Siamon Gordon
The Function of Leukocyte Immunoglobulin-Like Receptors in Self-Tolerance, Viral Recognition, and Regulation of Adaptive Responses	301	(14)
Marco Colonna
Winfried Barchet
EFFECTOR RESPONSES
Antimicrobial Peptides: Effectors of Innate Immunity	315	(30)
Michael Zasloff
Antimicrobial Proteins	345	(12)
Tomas Ganz
Robert I. Lehrer
Reactive Oxygen and Reactive Nitrogen Metabolites as Effector Molecules against Infectious Pathogens	357	(40)
Christian Bogdan
Chemokines	397	(20)
Bernhard Moser
Lipids	417	(16)
K. Frank Austen
Yoshihide Kanaoka
Role of Innate Immunity in Bacterial Infection	433	(22)
Peter Seiler
Ulrich Steinhoff
Stefan H. E. Kaufmann
Index	455