This first and second year medical school textbook provides a single text for the medical student to learn neuroanatomy, neurophysiology, neuropathology and clinical neurology. Key features of this volume include: up-to-date methodology and techniques; more than 300 high resolution illustrations, in full color on the accompanying CD Rom, that can be used as hand outs and slides; case studies and problem solving questions in each chapter designed for weekly discussion groups or courses entirely on neurological history and examination; additional chapters and case studies on CD Rom.

Elliott M. Marcus, M.D. is Professor Emeritus of Neurology, University of Massachusetts School of Medicine, Worcester, MA; Lecturer in Neurology, Tufts University School of Medicine; Chairman Emeritus, Department of Neurology St. Vincent Hospital and Fallon Clinic. Stanley Jacobson, Ph.D. is Professor of Anatomy and Cell Biology, Tufts University Health Science Campus, Boston, MA.

Preface

Dedication

SECTION I: INTRODUCTION TO BASIC NEUROBIOLOGY

Overview of the nervous system

21

(7)

The neuron

1

(2)

The central nervous system

3

(14)

Spinal Cord

3

(1)

Brain Stem

4

(2)

Diencephalon

6

(2)

Cerebrum

8

(6)

CNS pathways

14

(3)

Glands associated with the brain

17

(1)

Blood supply

17

(1)

Meninges

18

(1)

Ventricular system

19

(9)

Overview of localization of function and neurological diagnosis

28

(3)

Where is the disease located? What is the nature of the pathology?

1

(7)

The neurological history and examination

8

(3)

Diagnostic studies in Neurology

11

(20)

Neurocytology

31

Neurons

1

(7)

Myelin

8

(2)

Axoplasmic flow

10

(4)

Synapse

14

(6)

Supporting Cells of the Central Nervous System

20

(4)

Response of Nervous system to Injury

24

Degeneration

24

(2)

Regeneration

26

Neuroembryology

23

(5)

Introduction

1

(27)

Histogenesis

2

(2)

Neuronal Necrosis and apoptosis

4

(1)

Differentiation of CNS areas Ventricular System

5

(1)

Spinal Cord

5

(2)

Brain

7

(3)

Cranial Nerves

10

(3)

Cerebral cortex

13

(3)

Abnormal development

16

(12)

Basic Physiology

28

Cell physiology

1

(10)

Cell Membrane

1

(1)

Channels

2

(3)

Potassium Channels

5

(6)

Nerve Physiology

11

Action Potential

10

(1)

Sodium Channels

11

(4)

Saltatory Conduction

15

(2)

Calcium channels

17

(8)

SECTION II: REGIONAL APPROACH TO NEUROANATOMY AND LOCALIZATION

Skeletal Muscle and Nerve-Muscle Junction

25

(2)

Gross Structure and function

1

(4)

Molecular Architecture of Contraction

5

(4)

Nerve Muscle Junction

9

(3)

Disease of Muscle

12

(1)

Muscular Dystrophies

12

(4)

Myotonic Dystrophy

Congenital Myopathies

16

(2)

Acquired Disorders of Muscle

18

(1)

Disease of the Neuromuscular Junction

19

(8)

Spinal Cord: Structure and Physiology

27

Anatomy

1

(3)

Segmental functions

4

(2)

Reflexes

6

(3)

Membrane basis of integration

9

(3)

Stretch receptors

12

(5)

Lamination in spinal cord gray matter

17

(2)

Nociception and pain

19

(3)

Tracts

22

(3)

descending

23

(1)

Ascending

23

(2)

Disease of Peripheral Nerve and Nerve Root

25

(4)

Introduction

1

(28)

Mononeuropathies

4

(11)

Polyneuropathies

15

(4)

Radiculopathies

19

(10)

Clinical Considerations of the Spinal Cord

29

Spinal cord compression and transection syndromes

1

(2)

Extrinsic disorders

3

(7)

Intrinsic diseases: Segmental

10

System

17

(1)

Multifocal

17

Case History Problem Solving Part I: Spinal Cord, Nerve Root

9

(24)

Lesion Diagrams

1

(1)

Case Histories

2

(31)

Functional Anatomy of the Brain Stem

33

Introduction

1

(1)

Functional Localization in Coronal Sections of the brain stem

2

(18)

Functional Centers in the Brain Stem

20

(5)

Localization of Disease Processed in the Brain Stem

25

(5)

Brain Stem and Eye Movements

30

Cranial Nerves

25

Components

1

(22)

Function of each cranial nerve

23

(1)

Effects of Extrinsic Lesions on Cranial Nerves

23

(1)

Voluntary Control of the Cranial Nerves

23

Brain Stem: Clinical Considerations

21

Differentiation of extrinsic and intrinsic lesions Extrinsic disorders

2

(6)

Intrinsic disorders

8

(1)

Vascular

8

(11)

Neoplastic

19

(1)

Multiple Sclerosis

19

Case History Problem Solving Part II: Brain Stem and Cranial Nerves

9

(12)

Lesion Diagrams

1

(1)

Case Histories

2

(19)

Diencephlaon

21

introduction

1

(1)

Nuclei of the thalamus

2

(1)

Functional organization of Thalamus

3

(4)

White Matter of the diencephalon

7

(1)

Relationship between the thalamus and the cerebral cortex

8

(1)

Subthalamus

9

(3)

Major Sensory Pathways of the CNS

12

(4)

SECTION III: MAJOR SYSTEMS

Hypothalamus, Neuroendocrine and Autonomic systems

16

(12)

Introduction

1

(1)

Hypothalamus

2

(3)

Neuroendocrine systems

5

(2)

Hormnes produced in by hypothalamus

7

(1)

Hormones produced by Adenohypophysis

7

(3)

Hypothalamus and the Autonomic system

10

(1)

Hypothalamus and Emotions

11

(1)

Autonomic Nervous system

12

(16)

Cerebral cortex, Cytoarchitecture, Functional localization

28

Anatomy

1

(7)

Functional localization

8

(8)

Subcortical white matter

16

(8)

Neurophysiology and Seizure Correlations

24

(2)

Motor System I: Reflex Activity and Cortical Motor Function

26

Reflexes and central pattern generators

1

(7)

Motor functions of cerebral cortex

8

(2)

Primary Motor Cortex

10

(6)

Premotor Cortex

16

(1)

Pyramidal Tract

17

(2)

Cortical control of eye movements

19

(4)

Prefrontal cortex

23

(2)

Gait disorders in the elderly

25

Motor System III: Basal Ganglia and Movement Disorders

24

Structure, connections, transmitters

1

(6)

Parkinson's disease

7

(8)

Choreiform disorders

15

(6)

Other dyskinesias

21

(1)

Motor System III: Cerebellum and Movement

22

Anatomy

1

(5)

Syndromes of the lobes

6

(8)

Vascular Syndromes

14

(2)

Spinocerebellar Degenerations

16

(5)

Overview of Tremor

21

Somatosensory Function and the Parietal Lobe

10

(17)

PostCentral gyrus and Syndromes

1

(6)

Parietal lobules: Dominant Hemisphere syndromes

7

(20)

Non-Dominant Hemisphere Syndromes

8

(19)

Limbic System

27

Anatomy

1

(5)

Emotions

6

(2)

Hippocampus

8

(6)

Temporal lobe and Seizures

14

(6)

Prefrontal Cortex and Emotions

20

(1)

Visual system

20

The eye

1

(2)

The retina

3

(4)

Pathways, Lesions and Syndromes

7

(5)

Occipital Cortex and Syndromes

12

(6)

Speech, Language, Cerebral Dominance and the Aphasias

18

Language dominance and development

1

(5)

Aphasia: nnonfluent

6

(9)

nonfluent

9

(6)

Visual Agnosia

15

(2)

Aparaxia

17

(1)

Nondominant functions

17

Case History Problem Solving III: Cortical Localization

9

(22)

Case Histories

1

(30)

Disease of the Cerebral Hemispheres: I: Vascular Syndromes

31

(3)

Ischemic occlusive

1

(3)

Embolic disease

Carotid

4

(7)

Middle Cerebral Artery

11

(5)

Anterior Cerebral Artery

16

(2)

Posterior Cerebral Artery

18

(1)

Emboism

19

(3)

Intracerebral hemorrhage

22

(2)

Subarachnoid hemorrhage

24

(10)

Disease of the Cerebral Hemispheres: II. Non Vascular

34

Trauma

1

(6)

Neoplasms

7

(11)

Infections

18

(Non bacterial on CD ROM)

System disorders

Disorders of myelin

Case History Problem Solving IV: Cerebral Hemispheres

11

(17)

Lesion diagrams

Case Histories

SECTION IV: COMPLEX FUNCTIONS

Alterations in Consciousness: Seizures, Coma, and Sleep

28

Basic definitions

1

(2)

Seizures and Epilepsy

3

(20)

Focal Epilepsy

3

(3)

General Epilepsy

6

(17)

Sleep

23

(5)

Coma

28

Learning, Memory, Amnesia, Dementias

20

Definitions

1

(1)

Stages of Human Memory

2

(3)

Disorders of Recent Memory

5

(2)

Wernicke' Korsakoff

5

(1)

Diencephalic Mechanisms

6

(1)

Hippocampal Lesion

7

(4)

Progressive Dementia

11

(1)

Case History Problem Solving: V: Part I General Case Histories

11

(2)

Case Histories

1

(12)

Case History Problem Solving V: Part II General Case Histories

13

Imaging Correlations Lesion Diagrams

1

(6)

Case Histories

7

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Integrated Neuroscience

9781402071645

1402071647

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