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An Introduction to Medicinal Chemistry

by
Edition:
5th
ISBN13:

9780199697397

ISBN10:
0199697396
Format:
Paperback
Pub. Date:
3/1/2013
Publisher(s):
Oxford University Press
List Price: $74.61

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Summary

An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style.

The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents.

Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills.

Online Resource Centre

The Online Resource Centre features:

For registered adopters of the book:
DT Answers to end-of-chapter questions
DT Figures from the book
DT Power Point slides
DT Test Bank questions

For students:
DT Multiple Choice Questions
DT Web articles
DT Molecular Modelling Exercises
DT 3D Rotatable structures

Table of Contents


1. Drugs and drug targets - an overview
PART A Drug targets- structure and function
2. Protein structure and function
3. Enzymes: structure and function
4. Receptors: structure and function
5. Receptors and signal transduction
6. Nucleic acids: structure and function
PART B Pharmacodynamics and pharmacokinetics
7. Enzymes as drug targets
8. Receptors as drug targets
9. Nucleic acids as drug targets
10. Miscellaneous drug targets
11. Pharmacokinetics and related topics
Case study 1: Statins
PART C Drug discovery, design, and development
12. Drug discovery: finding a lead
13. Drug design: optimizing target interactions
14. Drug design: optimizing access to the target
15. Getting the drug to market
Case study 2: The design of ACE inhibitors
Case study 3: Artemisinin and related antimalarial drugs
Case study 4 : The design of oxamniquine
PART D Tools of the trade
16. Combinatorial synthesis
17. Computers in medicinal chemistry
18. Quantitative structure-activity relationships (QSAR)
Case study 5: De novo design of a thymidylate synthase inhibitor
PART E Selected topics in medicinal chemistry
19. Antibacterial agents
20. Antiviral agents
21. Anticancer agents
22. Cholinergics, anticholinergics, and anticholinesterases
23. Drugs acting on the adrenergic nervous system
24. Opioid analgesics
25. Antiulcer agents
Case study 6: Steroidal anti-inflammatory agents
Case Study 7: Design of a novel antidepressant
Appendices


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