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An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style.
The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents.
Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills.
Online Resource Centre
The Online Resource Centre features:
For registered adopters of the book: DT Answers to end-of-chapter questions DT Figures from the book DT Power Point slides DT Test Bank questions
For students: DT Multiple Choice Questions DT Web articles DT Molecular Modelling Exercises DT 3D Rotatable structures
Table of Contents
1. Drugs and drug targets - an overview PART A Drug targets- structure and function 2. Protein structure and function 3. Enzymes: structure and function 4. Receptors: structure and function 5. Receptors and signal transduction 6. Nucleic acids: structure and function PART B Pharmacodynamics and pharmacokinetics 7. Enzymes as drug targets 8. Receptors as drug targets 9. Nucleic acids as drug targets 10. Miscellaneous drug targets 11. Pharmacokinetics and related topics Case study 1: Statins PART C Drug discovery, design, and development 12. Drug discovery: finding a lead 13. Drug design: optimizing target interactions 14. Drug design: optimizing access to the target 15. Getting the drug to market Case study 2: The design of ACE inhibitors Case study 3: Artemisinin and related antimalarial drugs Case study 4 : The design of oxamniquine PART D Tools of the trade 16. Combinatorial synthesis 17. Computers in medicinal chemistry 18. Quantitative structure-activity relationships (QSAR) Case study 5: De novo design of a thymidylate synthase inhibitor PART E Selected topics in medicinal chemistry 19. Antibacterial agents 20. Antiviral agents 21. Anticancer agents 22. Cholinergics, anticholinergics, and anticholinesterases 23. Drugs acting on the adrenergic nervous system 24. Opioid analgesics 25. Antiulcer agents Case study 6: Steroidal anti-inflammatory agents Case Study 7: Design of a novel antidepressant Appendices