Introduction to Peptides and Proteins

by Langel; Ulo

• ISBN13: 9781420064124
• ISBN10: 1420064126
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-11-18
• Publisher: CRC Press

Summary

Authored by key players in the field, this volume offers a relevant presentation of peptide and protein chemistry. It provides key insight into the fast-developing field of proteomics, including structural and functional aspects, biochip development, and clinical potential. The authors include chapters on bioinformatics and proteomics and present the latest information on concerns over protein degradation and the post-translational modifications of proteins and peptides. The book also includes a section on protein coupled diseasesthat presents increasing evidence of the impact of protein misfolding and various deviations in neurodegenerative diseases, and the role of proteins in cancer.

Table of Contents

Preface	p. ix
Further Reading	p. xi
Biography	p. xiii
Introduction to Part I	p. 5
From Building Blocks to 3-D Structure
Amino Acids	p. 5
Noncovatent Interactions	p. 21
Structural Organization of Proteins	p. 35
Protein Biosynthesis and Posttranslational Modifications
The Biosynthesis of Proteins	p. 61
Posttranslational Modifications	p. 81
Folding of Proteins
Protein Folding	p. 101
Intracellular Sorting of Proteins	p. 123
Protein Degradation
Protein Turnover	p. 137
Introduction to Part II
Purification and Characterization of Proteins	p. 147
Crystallography and X-Ray Diffraction	p. 159
Optical Spectroscopy	p. 167
Nuclear Magnetic Resonance (NMR)	p. 177
Methods to Follow Protein Folding	p. 189
Mass Spectrometry	p. 195
Chemical Synthesis of Peptides and Proteins	p. 199
Introduction to Part III
Protein Engineering and Gene Silencing	p. 215
Protein-Ligand Interactions	p. 229
Sequence Analysis and Function Prediction	p. 245
Protein Structure Prediction	p. 257
Proteomics	p. 263
Introduction to Part IV
Enzymes	p. 283
Nucleic Acid-Binding Proteins	p. 313
Cell Surface Receptors and Signaling	p. 323
Membrane Proteins	p. 337
Antibodies	p. 343
Fibrous Proteins	p. 355
Selected Classes of Bioactive Peptides	p. 365
Introduction to Part V
Misfolding-Based Diseases	p. 381
Miscleavage-Based Diseases	p. 389
Missequence-Based Diseases	p. 395
Peptides and Proteins as Drugs	p. 401
Index	p. 415
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