An Introduction to Tissue-Biomaterial Interactions

by Dee, Kay C.; Puleo, David A.; Bizios, Rena

• ISBN13: 9780471253945
• ISBN10: 0471253944
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-09-02
• Publisher: Wiley-Liss

Summary

An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body's wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactionsThe text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today's and tomorrow's implantable biomedical devices.

Author Biography

Dr. Rena Bizios received her B.S. in Chemical Engineering from the University of Massachusetts, M.S. in Chemical Engineering from the California Institute of Technology, and Ph.D. in Biomedical Engineering from the Massachusetts Institute of Technology. She is currently a Professor with the faculty of the Biomedical Engineering Department, School of Engineering at Rensselaer Polytechnic Institute in Troy, New York.

Dr. Kay C Dee earned her M.Eng. and Ph.D. degrees in biomedical engineering from Rensselaer Polytechnic Institute. Her research has been awarded by the Biomedical Engineering Society and the National Science Foundation. Dr. Dee has been voted "Teacher of the Year" by the biomedical engineering seniors each of the four years that she has been at Tulane University, and she received the University-wide Inspirational Undergraduate Professor Award in 2001.

Dr. David Puleo received his B.S. and Ph.D. degrees in Biomedical Engineering from Rensselaer Polytechnic Institute, and is currently an Associate Professor in the Center for Biomedical Engineering at the University of Kentucky.

Table of Contents

Preface.

Acknowledgments.

Introduction.

Biomaterials.

Proteins.

Protein-Surface Interactions.

Blood-Biomaterial Interactions and Coagulation.

Inflammation and Infection.

The Immune System and Inflammation.

Wound Healing.

Biomaterial Surface and the Physiological Environment.

Biocompatibility.

Example 1: Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia.

Example 2: Replacing Joints and Teeth.

Answers to Quiz Questions.

Gloassry.

Index.