Liver Immunology : Principles and Practices

by Gershwin, M. Eric; Vierling, John M., M.D.; Manns, Michael P., M.D.

• ISBN13: 9781588298188
• ISBN10: 1588298183
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-11-25
• Publisher: Springer Verlag

Summary

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided. This volume will become a must-read for novice and expert alike. Liver Immunology: Principles and Practices covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format.

Table of Contents

Foreword: Contemporary Liver Immunology and Immunopathology: Obstacles and Opportunities	p. 1
A Short Primer on Fundamental Immunology	p. 15
Role and Function of Liver Sinusoidal Endothelial Cells	p. 25
Innate Immune Mechanisms in the Liver	p. 41
Antigen Processing and Presentation in the Liver	p. 49
Adaptive Immunity in the Liver	p. 61
Hepatic NK, NKT, and T Cells	p. 71
Cytokines in Liver Health and Disease	p. 83
Prevalence and Significance of Autoantibodies in Acute and Chronic Liver Diseases and Hepatocellular Carcinoma	p. 95
The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis	p. 111
Clinical Use of Immunopathology Techniques in Liver Diseases	p. 123
Tumor Immunology: Hepatocellular Carcinoma, Cholangiocarcinoma, Metastatic Neoplasms	p. 137
Innate and Adaptive Immune Responses to Bacterial and Parasite Infections: Clinicopathological Consequences	p. 153
Immune Response to Hepatitis A and E Viruses: Role in Disease Pathogenesis unci Viral Elimination	p. 163
Role of the Immune Response in Hepatitis B: Determinants of Severity, Chronicity, and Response to Antiviral Therapy	p. 179
Immune Responses in Acute and Chronic Hepatitis C: Implications for Prognosis and Therapy	p. 193
Immununopathogenesis of Extrahepatic Manifestations in HAV, HBV, and HCV Infections: Importance of Recognition and Therapy	p. 209
Immunogenetics of Autoimmune Liver Disease: Risk factors for Susceptibility and Progression	p. 221
Primary Biliary Cirrhosis and Autoimmune Cholangitis	p. 235
Sclerosing Cholangitis: Primary and Secondary	p. 249
Autoimmune Hepatitis	p. 263
Unique Aspects of Autoimmune Hepatitis in Children	p. 277
Overlap Syndromes of Autoimmune Hepatitis With Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis	p. 285
Animal Models of Autoimmune Liver Diseases	p. 293
The Immune Response in the Pathogenesis of Alcoholic Liver Disease	p. 309
Immunomodulation Therapy for Alcoholic Hepatitis: Rationale and Efficacy	p. 323
Role of Immune Response in Nonalcoholic Fatty Liver Disease: Evidence in Human and Animal Studies	p. 337
Mechanisms of Acute Liver Failure	p. 349
Immune Mechanisms in Drug-Induced Hepatotoxicity: Therapeutic Implications	p. 363
Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics	p. 375
Clinical Use of Immunosuppressive Drugs to Control the Immune Response	p. 391
Hepatic Complications of Hematopoietic Cell Transplantation	p. 409
Acute and Chronic Rejection of the Liver Allograft	p. 423
Immunological Tolerance in Allo- and Xenografts	p. 433
Autoimmune Diseases in Transplanted Livers	p. 451
Immunopathogenesis and Outcomes of Recurrent Hepatitis C	p. 459
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