Foreword | |
Contributors | |
Instrumentation | |
Definitions and Explanations | |
References | |
A Mass Spectrometer's Building Blocks | |
Ion Sources | |
Mass Analyzers | |
Detectors | |
References | |
Tandem Mass Spectrometry | |
Tandem MS Analyzer Combinations | |
Ion Activation Methods | |
References | |
Separation Methods | |
Chromatography | |
Electric-Field Driven Separations | |
References | |
Interpretation | |
Introduction to Mass Spectra Interpretation: Organic Chemistry | |
Basic Concepts | |
Inlet Systems | |
Physical Bases of Mass Spectrometry | |
Theoretical Rules and Approaches to Interpret Mass Spectra | |
Practical Approaches to Interpret Mass Spectra | |
References | |
Sequencing of Peptides and Proteins | |
Basic Concepts | |
Tandem Mass Spectrometry of Peptides and Proteins | |
Peptide Fragmentation Nomenclature | |
Technical Aspects and Fragmentation Rules | |
Why Peptide Sequencing? | |
De Novo Sequencing | |
Peptide Derivatization Prior to Fragmentation | |
Acknowledgments | |
References | |
Online Tutorials | |
Optimizing Sensitivity and Specificity in Mass Spectrometric Proteome Analysis | |
Quantitation | |
Peptide and Protein Identification | |
Success Rate and Relative Dynamic Range | |
Summary | |
References | |
Applications | |
Doping Control | |
References | |
Oceanography | |
References | |
"Omics" Applications | |
Introduction | |
Genomics and Transcriptomics | |
Proteomics | |
Metabolomics | |
SPace Sciences | |
Introduction | |
Origins | |
Dynamics | |
The Space MS Paradox | |
A Brief History of Space MS | |
GENESIS and the Future | |
References | |
Bioterrorism | |
What is Bioterrorism? | |
Some Historical Accounts of Bioterrorism | |
Geneva Protocol of 1925 and Biological Weapons Convention of 1972 | |
Categories of Biothreat Agents | |
Challenges | |
MS Identification of Biomarker Proteins | |
Development of New Therapeutics and Vaccines Using Immunoproteomics | |
References | |
Imaging of Small Molecules | |
SIMS Imaging | |
Biological Applications (Cells, Tissues, and Pharmaceuticals) | |
Catalysis | |
Forensics | |
Semiconductors | |
The Future | |
References | |
Utilization of Mass Spectrometry in Clinical Chemistry | |
Introduction | |
Where are Mass Spectrometers Utilized in Clinical Applications? | |
Most Common Analytes Detected by Mass Spectrometers | |
Multianalyte Detection of Clinical Biomarkers, The Real Success Story | |
Quantitative Profiling | |
A Clinical Example of the Use of Mass Spectrometry | |
Demonstrations of Concepts of Quantification in Clinical Chemistry | |
Polymers | |
Introduction | |
Instrumentation, Sample Preparation | |
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