Mechanisms of the Glaucomas

by Tombran-Tink, Joyce, Ph.D.; Barnstable, Colin J.; Shields, M. Bruce

• ISBN13: 9781588299567
• ISBN10: 1588299562
• Edition: CD
• Format: Hardcover
• Copyright: 2008-06-03
• Publisher: Humana Pr Inc

Summary

The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma, from epidemiology and genetics through molecular, cellular, and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma. Book jacket.

Table of Contents

Preface	p. vii
Contributors	p. xv
Companion CD	p. xix
Epidemiology of Glaucoma
Age and Racial Variation in the Prevalence of Open-Angle Glaucoma in the USA	p. 3
Epidemiology of and Risk Factors for Primary Open-Angle Glaucoma	p. 19
The Reykjavik Eye Study on Prevalence of Glaucoma in Iceland and Identified Risk Factors	p. 35
Defined Glaucoma in Chinese Population	p. 49
The Wroclaw Epidemiological Study Screening Possibilities of Glaucoma Detection	p. 63
Mechanisms of Intraocular Pressure Elevation in the Glaucomas
Pretrabecular Mechanisms of Intraocular Pressure Elevation	p. 83
Glaucomatous Changes in the Trabecular Meshwork	p. 99
Trabecular Mechanisms of Intraocular Pressure Elevation Pseudoexfoliation Syndrome	p. 117
Post-Trabecular Glaucomas with Elevated Episcleral Venous Pressure	p. 139
Angle-Closure Glaucomas Anterior (Pulling) Mechanisms	p. 159
Angle-Closure Glaucomas Posterior (Pushing) Mechanisms with Pupillary Block	p. 167
Angle-Closure Glaucomas Posterior (Pushing) Mechanisms Without Pupillary Block	p. 173
Genetics of Glaucoma
Genetics and Glaucoma Susceptibility	p. 191
Myocilin Mutations and Their Role in Open-Angle Glaucoma	p. 205
The Functional Role of Myocilin in Glaucoma	p. 219
Roles of CYP1B1, Optineurin, and WDR36 Gene Mutations in Glaucoma	p. 233
Genetic Association in the Open-Angle Glaucomas	p. 275
ApoE Polymorphisms and Severity of Open-Angle Glaucoma	p. 289
Molecular and Cellular Responses in the Eye to Glaucoma
Changes in Aqueous Humor Dynamics with Age and Glaucoma	p. 311
Mechanosensitive Genes in the Trabecular Meshwork at Homeostasis Elevated Intraocular Pressure and Stretch	p. 329
Reactive Astrocytes in the Glaucomatous Optic Nerve Head Protective and Destructive Mechanisms	p. 363
Optic Neuropathy and Ganglion Cell Degeneration in Glaucoma Mechanisms and Therapeutic Strategies	p. 393
Proteomics in Defining Pathogenic Processes Involved in Glaucomatous Neurodegeneration	p. 425
Proteomic Advances Toward Understanding Mechanisms of Glaucoma Pathology	p. 443
Molecular and Cellular Responses in the Eye to Glaucoma Ocular Gene Expression in Experimental Glaucoma	p. 459
Ocular Tissue and Psychophysiological Responses in Glaucoma
Ocular Biomechanics in Glaucoma	p. 471
Intraocular Pressure, Perfusion Pressure, and Optic Nerve Energy Metabolism	p. 491
Optic Nerve Physiology and Mechanisms of Glaucomatous Atrophy	p. 517
Psychophysiology of Glaucoma From Form to Function	p. 527
Models of Glaucoma
The Primate Model of Experimental Glaucoma	p. 551
Involvement of Inflammation in a Mouse Model of Inherited Pigmentary Glaucoma	p. 579
Use of Purified Retinal Ganglion Cells for an In Vitro Model to Study Glaucoma	p. 601
Therapeutic Modalities
Pharmacological Therapies for Managing Glaucoma	p. 611
Redox-Based Therapies for Neuroprotection	p. 645
Neuroprotective Signaling Pathways in Glaucoma	p. 657
Role of Selective Laser Trabeculoplasty in the Management of Glaucoma	p. 683
Mechanisms and Mechanics of Incisional Surgery for Glaucoma	p. 693
Aqueous Shunts	p. 715
New Approaches to the Surgical Management of the Glaucomas	p. 739
Index	p. 753
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