Medicinal Chemistry An Introduction

by Thomas, Gareth

• ISBN13: 9780470025987
• ISBN10: 0470025980
• Edition: 2nd
• Format: Paperback
• Copyright: 2008-01-22
• Publisher: Wiley-Interscience

Summary

"Medicinal Chemistry, Second Edition provides a comprehensive, balanced introduction to this evolving, multi-disciplinary subject. The book carefully explains fundamental principles, assuming little in the way of prior knowledge. It opens with a broad overview of medicinal chemistry followed by chapters that cover the principal methods used in drug design and the isolation of drugs from natural sources. Subsequent chapters discuss more specialised aspects of medicinal chemistry and outline drug and analogue synthesis, development and production, Each chapter contains self-assessment questions, numerous examples and a wide variety of applications." "Medicinal Chemistry, Second Edition will prove invaluable to students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology whose courses include medicinal chemistry units."--BOOK JACKET.

Author Biography

Dr Gareth Thomas, The University of Portsmouth, UK.

Table of Contents

Preface

Acknowledgements.

Abbreviations.

An Introduction to Drugs, their Action and Discovery.

Drug Structure and Solubility.

Structure-activity and quantitative structures relationships.

Computer aided drug design.

Combinatorial Chemistry.

Drugs from natural sources.

Biological Membranes.

Receptors and Messengers.

Enzymes.

Nucleic Acids.

Pharmacokinetics.

Drug metabolism.

Complexes and chelating agents.

Nitric oxide.

An Introduction to drug and analogue synthesis.

Drug Development and Production.

Selective further reading.

Answers to Questions.

Index.

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