The fully revised and enhanced second edition of this monumental, best-selling textbook and reference presents a comprehensive, experience- and evidence-based review of pigmented lesions encompassing the biology, diagnosis, and treatment of melanocytic proliferations and disorders, including malignant melanoma. Incorporating the latest findings from the fields of light microscopy, immunohistochemistry, and flow cytometry, the book brings readers up to date on the most current thinking in the field. Beginning with a discussion of the clinical approach to the patient and a full-color clinical atlas of melanocytic proliferations and their common mimicks, the book's further chapters highlight basic melanocytic biology and morphology, a diagnostic approach to both benign and malignant melanocytic neoplasms, metastatic patterns, and treatment options. The histopathologic interpretation of melanocytic lesions presents one of the most difficult challenges to the anatomic pathologist, a challenge that reflects clinical diagnostic difficulties faced by primary care physicians, dermatologists, and surgeons who rely on the microscopic interpretation to provide definitive diagnosis and the basis for treatment planning. The three world-renowned authors offer both traditional and novel concepts for interpretation, diagnosis, and treatment, from light microscopy to the very latest information about molecular investigational and diagnostic techniques.