Metabolic Encephalopathy

by Mccandless, David W.

• ISBN13: 9780387791098
• ISBN10: 0387791094
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-09-29
• Publisher: Springer Verlag

Summary

Metabolic Encephalopathy is meant to combine and correlate animal and human studies. In many cases, alterations in the neurochemistry of humans and experimental animal models are similar. It is hoped that increased awareness of the importance of early diagnosis and treatment of these disorders may result in a lowering of the incidence of structural changes and morbidity. These metabolic encephalopathies hold a special fascination for both basic scientists and clinical investigators because they are accessible, treatable, and there exist good animal models for further study. Therefore, this book assembles both basic and clinical neuroscience issues in the treatment of specific metabolic encephalopathies such as uremia, Wernicke's disease, epilepsy, stroke, hepatic encephalopathy, pediatric encephalopathies, inborn errors of metabolism, toxins such as lead, depression, cerebral infections, kernicterus, Wilson disease, HIV encephalopathy, and many others. Book jacket.

Table of Contents

Functional Anatomy of the Brain	p. 1
Brain Metabolic Adaptations to Hypoxia	p. 15
Hypoglycemic Brain Damage	p. 31
Experimental Ischemia: Summary of Metabolic Encephalopathy	p. 41
Stroke-Clinical Features	p. 69
The Role of Animal Models in the Study of Epileptogenesis	p. 85
Seizure-Induced Neuronal Plasticity and Metabolic Effects	p. 113
Metabolic Encephalopathies in Children	p. 137
Pathophysiology of Hepatic Encephalopathy: Studies in Animal Models	p. 149
Hepatic Encephalopathy	p. 181
Uremic and Dialysis Encephalopathies	p. 201
Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability	p. 235
Alcohol, Apoptosis, and Oxidative Stress	p. 261
Wernicke's Encephalopathy	p. 281
The Genetics of Myelination in Metabolic Brain Disease: The Leukodystrophies	p. 303
Bilirubin Encephalopathy	p. 321
Infectious and Inflammatory Metabolic Encephalopathies: Concepts in Pathogenesis	p. 333
Major Depression and Metabolic Encephalopathy: Syndromes More Alike Than Not?	p. 349
Attention-Deficit/Hyperactivity Disorder as a Metabolic Encephalopathy	p. 371
Brain Damage in Phenylalanine, Homocysteine, and Galactose Metabolic Disorders	p. 393
Wilson Disease	p. 459
Metabolic Abnormalities in Alzheimer Disease	p. 483
Prions and the Transmissible Spongiform Encephalopathies	p. 531
Lead Encephalopathy	p. 551
Index	p. 573
Table of Contents provided by Ingram. All Rights Reserved.