9780470654897

Microneedle-mediated Transdermal and Intradermal Drug Delivery

by ; ; ;
  • ISBN13:

    9780470654897

  • ISBN10:

    0470654899

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2012-03-05
  • Publisher: Wiley-Blackwell
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Summary

One of the latest techniques in drug delivery, microneedles are used for administering a wide range of drug substances used to treat various medical conditions. Thorough background information is included providing a history of the field. Various methods used to produce micorneedles are described as well as a snapshot of the future directions within the industry. Written by highly qualified authors, this new text is the only title providing a comprehensive review of microneedle research in the fields of transdermal and intradermal drug delivery.

Author Biography

Ryan F. Donnelly, Senior Lecturer in Pharmaceutics, School of Pharmacy, Queen's University Belfast, UK

Thakur Raghu Raj Singh, Lecturer in Pharmaceutics, School of Pharmacy, Queen's University Belfast, UK

Desmond I.J. Morrow, Honorary Research Fellow, School of Pharmacy, Queen's University Belfast, UK

A. David Woolfson, Chair in Pharmaceutics and Head of the School  of Pharmacy, Queen’s University Belfast, UK

Table of Contents

Prefacep. ix
About the Authorsp. xiii
Transdermal Drug Deliveryp. 1
Genesis of transdermal drug deliveryp. 1
Skin anatomyp. 2
The epidermisp. 2
The stratum corneump. 4
The dermisp. 6
Skin appendagesp. 6
Routes to percutaneous drug absorptionp. 7
Facilitated transdermal drug deliveryp. 11
Cryopneumatic and photopneumatic technologiesp. 12
Sonophoresis (low-frequency ultrasound)p. 12
Iontophoresisp. 13
Electroporationp. 14
Jet injectionp. 14
Microneedlesp. 15
Referencesp. 15
Microneedles: Design, Microfabrication and Optimizationp. 20
Introductionp. 20
Methods of fabricating microneedlesp. 21
Microfabrication of silicon microneedlesp. 22
Microfabrication of metal and other types of MNsp. 31
Microfabrication of polymeric microneedlesp. 34
Optimization to MN design for transdermal drug deliveryp. 46
Conclusionp. 49
Referencesp. 51
Microneedle Applicator Designs for Transdermal Drug Delivery Applicationsp. 57
Introductionp. 57
Considerations of microneedle applicators designsp. 72
Conclusionp. 76
Referencesp. 76
Transdermal Delivery Applicationsp. 79
Introductionp. 79
Transdermal drug deliveryp. 79
Partition co-efficient between 1 and 3p. 80
A relatively low melting pointp. 80
A molecular weight less than 500 Dap. 81
Unionizedp. 81
Modulation of transdermal penetration using microneedlesp. 82
Transdermal delivery using solid microneedlesp. 83
Transdermal delivery of low molecular weight compounds (RMM < 600 Da) in vitro using solid microneedlesp. 84
Transdermal delivery of low molecular weight compounds (RMM < 600 Da) in vivo using solid microneedlesp. 86
Transdermal delivery of high molecular weight compounds (RMM > 600 Da) in vitro using solid microneedlesp. 88
Transdermal delivery of high molecular weight compounds (RMM > 600 Da) in vivo using solid microneedlesp. 89
Transdermal delivery using hollow microneedlesp. 91
Transdermal delivery of low molecular weight compounds (RMM < 600 Da) in vitro using hollow microneedlesp. 91
Transdermal delivery of low molecular weight compounds (RMM < 600 Da) in vivo using hollow microneedlesp. 92
Transdermal delivery of high molecular weight compounds (RMM > 600 Da) in vitro using hollow microneedlesp. 93
Transdermal delivery of high molecular weight compounds (RMM > 600 Da) in vivo using hollow microneedlesp. 93
Transdermal delivery using biodegradable microneedlesp. 96
Transdermal delivery of low molecular weight compounds in vitro using biodegradable MNp. 96
Transdermal delivery of low molecular weight compounds in vivo using biodegradable MNp. 98
Transdermal delivery of high molecular weight compounds in vitro using biodegradable MNp. 98
Transdermal delivery of high molecular weight compounds in vivo using biodegradable MNp. 100
Microneedles in combination with other enhancement strategiesp. 102
Conclusionp. 105
Referencesp. 107
Microneedle-mediated Intradermal Deliveryp. 113
Introductionp. 113
Vaccine deliveryp. 113
Vaccinationp. 113
Intradermal vaccinationp. 116
p. 117
Skin immune responsep. 117
Conventional strategies for intradermal vaccine deliveryp. 118
Coated microneedlesp. 120
'Poke and Patch' approachesp. 129
Hollow microneedlesp. 131
Dissolving/biodegrading polymeric microneedlesp. 133
Epidermal gene deliveryp. 135
Intradermal delivery of photosensitizers for photodynamic therapyp. 139
Microneedle-mediated intradermal delivery of 5-aminolevulinic acid and derivativesp. 141
Microneedle-mediated intradermal delivery of preformed photosensitizersp. 143
Intradermal delivery of nanoparticles144
Conclusionp. 146
Referencesp. 147
Clinical Application and Safety Studies of Microneedlesp. 152
Introductionp. 152
Clinical and safety consideration for MN applicationp. 153
Sensation of painp. 153
Recovery of micropores and possibility of infection following microneedle applicationp. 155
Erythemap. 156
Biocompatability and biodegradation of MN materialp. 157
Conclusionp. 159
Referencesp. 160
Microneedles: Current Status and Future Perspectivesp. 164
Introductionp. 164
Biological fluid sampling devicesp. 167
Ocular drug deliveryp. 172
Cosmetic applicationsp. 175
Industrial perspectivesp. 177
Hydrogel-forming microneedle arraysp. 179
Moving forwardsp. 181
Conclusionp. 184
Referencesp. 185
Indexp. 188
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