Molecular Aspects of Aging Understanding Lung Aging

by Rojas, Mauricio; Meiners, Silke; Le Saux, Claude Jourdan

• ISBN13: 9781118396247
• ISBN10: 1118396243
• Edition: 1st
• Format: Hardcover
• Copyright: 2014-06-03
• Publisher: Wiley-Blackwell

Summary

Molecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence. Covering universal themes in aging, such as the exhaustion of stem cells and subsequent loss of the regenerative refueling of organs as well as immunosenescence, this text illuminates new directions for research not yet explored in the still poorly investigated area of molecular mechanisms of lung aging. The molecular nature of general aging processes is explored with targeted coverage on how to analyze lung aging through experimental approaches.

Author Biography

Dr. Mauricio Rojas is an Assistant Professor in the Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh.

Silke Meiners, PhD is a Research Group Leader from the Comprehensive Pneumology Center in Munich.

Claude Jourdan Le Saux, PhD is an Assistant Professor in the Department of Medicine Division of Cardiology/Pulmonary and Critical Care, University of Texas Health Science Center at San Antonio, San Antonio, Texas, as well as a faculty member of the Barshop Institute for Longevity and Aging Studies Nathan Shock Aging Center of Excellence and Department of Cellular and Structural Biology.

Table of Contents

Section 1: Mechanisms of Aging
This section covers principal molecular aspects of organismal aging and cellular senescence and seeks to give an overview on known cellular pathways of aging. The topics will be mainly covered by basic scientists who are experts in the field of molecular aging pathways but will also give an overview on mechanisms of senescence in the lung.

Chapter 1:
Telomerase Function in Aging
Calado RT (National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. [e-mail])

Chapter 2:
Immunosenescence in Infection
(mainly focusing on CD8T cell responses)
Blackman MA (SourceTrudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA. [e-mail])
Or :
Age-related changes in immune function: effect on airway inflammation.
Busse PJ (Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. [e-mail])

Chapter 3:
Oxidants and metabolism
Finkel T (Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA, [e-mail])

Chapter 4:
Protein quality control in aging
Meiners S (Comprehensive Penumology Center, Helmholtz Center Munich, Max-Lebsche Platz 31, 81377 Munich, Germany, [e-mail])

Chapter 5:
Signaling networks in aging
Brunet A (Department of Genetics, Stanford University, CA 94305, USA, [e-mail])

Chapter 6:
Senescence in the lung
Lesaux Jordan C (Division of Cardiology, UT Health Science Center, San Antonio, MC 7872, USA, [e-mail])

Section 2: How to investigate aging in the lung

This shorter section will give an overview on the available animal models for aging and on studying gene expression. It also reviews analysis of lung function in mice models of age-related lung diseases.

Chapter 7:
Mouse models to study aging
Richardson A (Department of Cellular and Structural Biology, Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA. [e-mail])

Chapter 8:
Profiling candidates of aging
George A. Garinis (Institute of Molecular Biology and Biotechnology, FORTH, Vassilika Vouton, P.O.Box 1385, GR 711 10 Heraklion, Crete, Greece)

Chapter 9:
Use of animal models to explore lung aging
Neptune ER (Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, [e-mail])

Section 3: The aging lung
This section will give an overview on the development and on the physiological aging of the lung. It will also cover lung diseases that have been associated with premature aging of the lung.

Chapter 10:
Development and physiological aging of the lung
Pinkerton KE (Center for Health and the Environment, University of California, Davis, California 95616, USA, [e-mail])

Chapter 11:
Premature aging of the damaged infant lung
Filippone M or Baraldi E (E. Baraldi, Dept of Paediatrics, Via Giustiniani 3, 35128 Padova, Italy, E-mail: [e-mail])

(Chapter 12:
Age-related alterations in lung cancer
Malcolm C. Pike ???
He is at the Memorial Sloan-Kettering
http://www.mskcc.org/news/magazine/july-2009/malcolm-c-pike-joins-msk-epidemiology-service)

Chapter 13:
Premature aging in IPF
Rojas M (Interstitial Lung Diseases at the Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15213; [e-mail])

Chapter 14:
Lung infections and aging
Meyer KC (Department of Medicine, K4/930 Clinical Sciences Center, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792-9988, USA. [e-mail])

Chapter 14:
COPD as a disease of premature aging
Serge Adnot (INSERM U955, Hôpital Henri Mondor, AP-HP, Créteil, France, [e-mail])

Chapter 15:
Demography of Aging
David E. Bloom Harvard University (http://www.hsph.harvard.edu/pgda/)