Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics

by Pecorino, Lauren

• ISBN13: 9780199577170
• ISBN10: 019957717X
• Edition: 3rd
• Format: Paperback
• Copyright: 2012-06-18
• Publisher: Oxford University Press

Summary

Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The third edition ofThe Molecular Biology of Cancer: Mechanisms, Targets, and Therapeuticsoffers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Canceris an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control. Online Resource Centre The Online Resource Centre to accompanyThe Molecular Biology of Cancerfeatures: For students: DT Hyperlinked to primary literature articles featured in the text DT News feeds relevant to cancer biology, drawn from a variety of publications DT A web link library, giving access to relevant online resources For registered adopters of the book: DT Figures from the book, available to download DT A test bank of questions, with feedback linked to the book, for use in formative or summative assessment

Table of Contents

Introduction

DNA and stability: mutations versus repair

Regulation of gene expression

Growth factor signaling and oncogenes

The cell cycle

Growth inhibition and tumour suppressor genes

Apoptosis

Stem cells and differentiation

Metastasis

Infections and inflammation

Nutrients, hormones, and gene interactions

The cancer industry: drug development and clinical trial design

Cancer in the future: focus on diagnostics and immunotherapy

Table of Contents provided by Publisher. All Rights Reserved.