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Donald Wells Pfaffis a professor and head of the Laboratory of Neuroscience and Behavior at The Rockefeller University in New York City. Dr. Brigitte Kieffer is a French molecular neurobiologist known for her research of opiate receptors. Her areas of expertise include: molecular psychiatry, addiction, mood disorders, pain, and developmental disorders.
Preface | p. xi |
Mechanisms for the Regulation of State Changes in the Central Nervous System: An Introduction | p. 1 |
Elementary Central Nervous System Arousal | |
Mechanisms in the Animal Brain | |
Concepts and Mechanisms of Generalized Central Nervous System Arousal | p. 11 |
Modulation of Cortical Activation and Behavioral Arousal by Cholinergic and Orexinergic Systems | p. 26 |
Dopamine Signaling in the Dorsal Striatum Is Essential for Motivated Behaviors: Lessons from Dopamine-Deficient Mice | p. 35 |
Ablation of the Central Noradrenergic Neurons for Unraveling Their Roles in Stress and Anxiety | p. 47 |
Heightened States of Arousal: Sex and Fear | |
Neural Substrates for Sexual Preference and Motivation in the Female and Male Rat | p. 55 |
Motivational Influences on the Degree and Direction of Sexual Attraction | p. 61 |
Fear Conditioning and Long-term Potentiation in the Amygdala: What Really Is the Connection? | p. 88 |
Insights into the Pharmacological Potential of Estrogens and Phytoestrogens on Catecholamine Signaling | p. 96 |
Elementary Central Nervous System Arousal: Clinical Studies | |
Central Thalamic Contributions to Arousal Regulation and Neurological Disorders of Consciousness | p. 105 |
Intrinsic Brain Activity in Altered States of Consciousness: How Conscious Is the Default Mode of Brain Function? | p. 119 |
Detecting Awareness in the Vegetative State | p. 130 |
The Emotion-Cognition Interface | |
Neural Mechanisms Underlying Selective Attention to Threat | p. 141 |
Toward a Neurogenetic Theory of Neuroticism | p. 153 |
Gene Expression Is Altered in the Lateral Hypothalamus upon Activation of the mu Opioid Receptor | p. 175 |
Bipolar Disorder as Maladaptive Arousal: A Behavioral Model and Evidence | p. 185 |
Alertness and Attention | |
Underlying Mechanisms | |
Measuring Alertness | p. 193 |
Molecular Genetics of Attention | p. 200 |
Potential Anatomical Basis for Attentional Modulation of Hippocampal Neurons | p. 213 |
Cholinergic Mediation of Attention: Contributions of Phasic and Tonic Increases in Prefrontal Cholinergic Activity | p. 225 |
Neuronal Mechanisms Underlying Attention Deficit Hyperactivity Disorder: The Influence of Arousal on Prefrontal Cortical Function | p. 236 |
Placing Neuroanatomical Models of Executive Function in a Developmental Context: Imaging and Imaging-Genetic Strategies | p. 246 |
Functional Gene Variation in the Human Norepinephrine Transporter: Association with Attention Deficit Hyperactivity Disorder | p. 256 |
Circadian Rhythms in the Activation of Behavior | |
Physiologic Mechanisms of Arousal and Sleep | |
Circadian and Homeostatic Factors in Arousal | p. 263 |
Hypothalamic Regulation of Sleep and Arousal | p. 275 |
Associations between Sleep Loss and Increased Risk of Obesity and Diabetes | p. 287 |
Sleep Deprivation and Vigilant Attention | p. 305 |
Genomics of Sleep and Biological Clocks | |
Sleep and Wakefulness in Drosophila melanogaster | p. 323 |
Why Does Consciousness Fade in Early Sleep? | p. 330 |
Molecular Mechanisms of Sleep and Wakefulness | p. 335 |
The In(put)s and Out(put)s of the Drosophila Circadian Clock | p. 350 |
Peripheral Circadian Oscillators: Interesting Mechanisms and Powerful Tools | p. 358 |
Index of Contributors | p. 371 |
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