Molecular Diagnostics: The Key in Personalized Cancer Medicine

by Jorgensen; Jan Trost

• ISBN13: 9789814241441
• ISBN10: 981424144X
• Format: Trade Book
• Copyright: 2010-04-30
• Publisher: Pan Stanford

Summary

Written by key leaders in their fields, this unique compilation provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. Journeying through definitions of the pharmacodiagnostic concept, this unique guide explores a variety of subjects, including molecular cancer diagnostics linked to therapy, diagnostic molecular techniques, current ongoing research, drug-diagnostic co-development, regulatory issues around pharmacodiagnostics, and future aspects within personalized cancer medicine.

Author Biography

Jan T. Jørgensen is the senior principal scientist of global science at Dako Denmark A/S. Henrik Winther is the director of immunohistology at Dako Denmark A/S.

Table of Contents

Introduction	p. v
Developing Molecular Diagnostics in Cancer	p. 1
The Estrogen and Progesterone Receptors - Setting the Scene for Pharmacodiagnostics	p. 21
The Development of the HercepTest™ - From Bench to Bedside	p. 43
Predictive Biomarkers and Translational Cancer Medicine	p. 61
Pharmacodiagnostic Testing - Immunohistology	p. 87
In Situ Hybridisation for Pharmacodiagnostic Testing	p. 119
MammaPrint® Translating Research into a Diagnostic Test	p. 139
DNA Biomarkers in the Diagnosis and Management of Cancer	p. 165
Validating the Analytical Power and Parameters of an Immunohistochemical Test	p. 185
Drug and Pharmacodiagnostic Co-Development: Statistical Considerations	p. 207
Clinical Validation of Biomarkers in Cancer	p. 227
Pharmacogenomic Markers for Cancer Therapy	p. 251
Safety and Effective Biomakers in Oncology - A Regulatory Drug and Device Perspective	p. 275
Personalizing Treatment Selection for Breast Cancer	p. 297
Pharmacodiagnostics and Personalized Medicine in Cancer	p. 325
Table of Contents provided by Ingram. All Rights Reserved.