Molecular Endocrinology of Cancer

by Jonathan Waxman

• ISBN13: 9780521159494
• ISBN10: 0521159490
• Edition: 1st
• Format: Paperback
• Copyright: 2011-04-14
• Publisher: Cambridge University Press

Summary

One third of human cancers have a hormonal basis. Breast cancer, the most common cancer of women, is increasing in many countries, as is prostate cancer, the second most common cancer of men. Concurrently, molecular biology has refined the definition of hormones to include the interaction between tumor cells and both locally and distantly secreted factors. This volume in the series Cancer: Clinical Science in Practice considers aspects of hormonal cancer, including the molecular basis for the autocrine and paracrine regulation of cancer, molecular strategies for cancer detection, strategies in limiting the epidemic of hormonally related cancers, and new treatment approaches.

Table of Contents

Contributor List	p. vii
The Regulation of Cancer
The Type 1 Growth Factor Receptor Family, Their Ligands and Their Role in Human Cancers	p. 3
The Fibroblast Growth Factor Family and Their Receptors	p. 14
The Biological Role of Transforming Growth Factor Beta in Cancer Development	p. 51
Bombesin and Its Receptor	p. 79
Gonadotrophin-Releasing Hormone and Its Receptor	p. 102
Cytokines	p. 135
The Prevention of Endocrine-Dependent Tumours
Familial Cancer	p. 187
Diet	p. 216
The Biological Basis for Treatment of Endocrine-Dependent Tumours
Breast Cancer: New Biological Approaches to Treatment	p. 271
The Biological Basis for the Treatment of Prostate Cancer	p. 305
Carcinoid Tumour	p. 318
Edocrine Complications of Cancer Treatment
Humoral Hypercalcaemia	p. 347
Anaemia of Cancer	p. 380
Index	p. 407
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