Molecular Imaging for Integrated Medical Therapy and Drug Development

by Tamaki, Nagara

• ISBN13: 9784431980735
• ISBN10: 4431980733
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-11-01
• Publisher: Springer Verlag

Summary

This is a proceedings of "SYMPOSIUM FOR FUTURE DRUG DISCOVERY AND MEDICAL CARE ". This symposium intends to exchange ideas how to promote molecular imaging technology and also how to extend the technology to medical therapy and drug development. It is a suitable time to share the most recent experiences on the research fields with specialists around the world, as 3 years has passed after the start of the program. We will invite several worldwide leaders on the research fields in this symposium. It will be a great and unique opportunity to interactively exchange ideas and information among researchers covering drug development, molecular imaging and medical therapy including regenerative treatment and radiation therapy.

Table of Contents

Preface	p. V
Contributors	p. XI
Advances in Molecular Imaging	p. 1
New Molecular Imaging and Image-Guided Radiotherapy	p. 5
Hypoxia Imaging for Image-Guided Radiotherapy	p. 7
Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy	p. 19
Development of a Prototype 3D PET Scanner Using Semiconductor Detectors and Depth of Interaction Information	p. 30
A New PET Scanner with Semiconductor Detector Reveals Intratumoral Inhomogeneous Cell Activity with High Spatial and Energy Resolution	p. 42
A New Positron Emission Tomography (PET) Scanner with Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma	p. 52
Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small-Animal Imaging	p. 60
Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-annexin A5	p. 69
Quantification of Myocardial Blood Flow Using Rubidium-82 PET	p. 78
Molecular Imaging For Regenerative Treatment	p. 91
New Concepts for Molecular and Functional Imaging of the Heart: Implications for Regenerative Treatments	p. 93
Molecular Imaging of Angiogenesis	p. 105
Spontaneous In Vivo Regeneration of the Articular Cartilage Using a Novel Double-Network Hydrogel	p. 116
Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders: Perspectives for Translational Research and Clinical Application	p. 126
Noninvasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct	p. 139
Thermoreversible Gelation Polymer (TGP) Hydrogel as a Degradable Scaffold for Bone Marrow Stromal Cell Transplantation	p. 145
Beneficial Effects of Bone Marrow Stromal Cell Transplantation on Axonal Regeneration in Injured Spinal Cord	p. 152
Transplanted Bone Marrow Stromal Cells Improve Cognitive Function after Diffuse Axonal Injury in Rats	p. 158
Molecular Imaging and Future Perspectives of Brain Research	p. 165
Ultra-High Throughput Screening (uHTS) Chemical Genetics to Identify Novel Chronotherapeutics	p. 167
Cell Death and Autophagy	p. 176
Bioluminescent Imaging for Assessing Heterogeneous Cell Functions in the Mammalian Central Circadian Clock	p. 189
Early Postnatal Stress and the Serotonergic System in the Brain	p. 197
Neural Circuit Development and Plasticity Shaped by Glutamate Transporters	p. 207
Molecular and Functional Imaging for Drug Development and Elucidation of Disease Mechanisms Using Positron Emission Tomography (PET)	p. 222
Recent Trends in Drug Developments	p. 235
The Sea as a Source of New Drugs	p. 237
PET/AMS Applications in Drug Development	p. 250
Functional and Structural Analysis Reveals Dual Function on C-Terminal a Helix of Alg13 Protein	p. 260
Discovery of a First-in-Class Drug, a Prostaglandin D2 Antagonist, for the Treatment of Allergic Diseases	p. 281
Towards Developing a Golgi Simulator: Microfluidic Device Enabling Synthesis of a Tetrasaccharide	p. 288
An Efficient Strategy for the Exploration of Specific Inhibitors of Sialyltransferases	p. 294
Keyword Index	p. 302
Table of Contents provided by Ingram. All Rights Reserved.