Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissues

by Milz, S.; Benjamin, M.; Putz, Reinhard

• ISBN13: 9783540244745
• ISBN10: 3540244743
• Format: Paperback
• Copyright: 2005-07-30
• Publisher: Springer Nature

Summary

"The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated." "In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carried out at the extensor tendons of toes and fingers, at the transverse ligament of the atlas, at the transverse ligament of the acetabulum, and at the tendon of the superior oblique muscle and its trochlea. The molecular components of the extracellular matrix are detected with standardized immunohistochemical methods." "The results show that certain molecules only occur due to compressive stress, others due to tensile stress. The molecular spectrum of the extracellular matrix allows qualifying conclusions to the mechanical situation of a given part of the tissue." "The spatial expansion of the fibrocartilaginous adaptation zones in tendons and ligaments roughly corresponds with the zones subjected to compressive force; tensile stress alone does not result in a production of fibrocartilage."--BOOK JACKET.

Table of Contents

1 Introduction
1.1 General Remarks	1	(1)
1.2 Adaptation of Connective and Supportive Tissues to Their Respective Functions	2	(2)
1.3 Parameters of Functional Adaptation	4	(1)
2 Aim of the Study	5	(4)
2.1 Fundamental Considerations	5	(1)
2.2 Structure of the Present Study	5	(1)
2.3 Questions	6	(3)
3 Anatomical Structures Investigated	9	(8)
3.1 Extensor Tendons of the Toes in the Region of the Proximal Interphalangeal Joint	9	(1)
3.2 Extensor Tendons of the Hand in the Region of the MCP Joint	10	(1)
3.3 Transverse Ligament of the Atlas	11	(1)
3.4 The Transverse Ligament of the Acetabulum	12	(2)
3.5 Tendon and Trochlea of the Superior Oblique Muscle	14	(3)
4 Materials and Methods	17	(4)
4.1 Materials	17	(3)
4.1.1 Extensor Tendons of the Toes	17	(1)
4.1.2 Extensor Tendons of the Human Hand in the Region of the MCP Joint	17	(1)
4.1.3 The Transverse Ligament of the Atlas	18	(1)
4.1.4 The Transverse Ligament of the Acetabulum	19	(1)
4.1.5 Tendon and Trochlea of the Superior Oblique Muscle	20	(1)
4.2 Methodology of the Immunohistochemical Investigation	20	(1)
5 Results	21	(22)
5.1 Extensor Tendons of the Toes	23	(3)
5.1.1 Histological Findings	23	(1)
5.1.2 Immunohistochemical Findings	24	(2)
5.1.2.1 Collagens	24	(1)
5.1.2.2 Glycosaminoglycans	25	(1)
5.2 Extensor Tendons of the Hand in the Region of the MCP Joint	26	(5)
5.2.1 Histological Findings	26	(1)
5.2.2 Immunohistochemical Findings	26	(5)
5.2.2.1 Collagens	26	(3)
5.2.2.2 Glycosaminoglycans and Proteoglycans	29	(2)
5.3 The Transverse Ligament of the Atlas	31	(4)
5.3.1 Histological Findings	31	(1)
5.3.2 Immunohistochemical Findings	32	(3)
5.3.2.1 Collagens	33	(1)
5.3.2.2 Glycosaminoglycans and Proteoglycans	33	(2)
5.4 The Transverse Ligament of the Acetabulum	35	(3)
5.4.1 Histological Findings	35	(1)
5.4.2 Immunohistochemical Findings	35	(3)
5.4.2.1 Collagens	36	(2)
5.4.2.2 Glycosaminoglycans and Proteoglycans	38	(1)
5.5 Tendon and Trochlea of the Superior Oblique Muscle	38	(5)
5.5.1 Histological Findings	38	(1)
5.5.2 Immunohistochemical Findings	39	(6)
5.5.2.1 Collagens	39	(1)
5.5.2.2 Glycosaminoglycans and Proteoglycans	40	(3)
6 Discussion	43	(18)
6.1 Discussion of the Method	43	(1)
6.2 Discussion of the Present Study's Structure	44	(1)
6.3 Discussion of Results	45	(12)
6.3.1 Extensor Tendons of the Toes	45	(4)
6.3.2 Extensor Tendons of the Hands in the Region of the MCP Joint	49	(2)
6.3.3 The Transverse Ligament of the Atlas	51	(2)
6.3.4 The Transverse Ligament of the Acetabulum	53	(2)
6.3.5 Tendon and Trochlea of the Superior Oblique Muscle	55	(2)
6.4 Conclusions	57	(4)
7 Summary	61	(12)
Subject Index	73