Morphogenesis of Endothelium

by Rubanyi; Gabor M.

• ISBN13: 9789058230614
• ISBN10: 9058230619
• Format: Hardcover
• Copyright: 2000-09-20
• Publisher: CRC Press

Summary

The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. Embryonic growth and differentiation essentially depend on transport of nutrients and waste through the early vasculature, and certain events in morphogenesis are thought to be influenced by the hemodynamic forces of the beating heart. The vasculature not only serves as a 'nutrient and waste pipeline' but is also a major communication system between distant organs and tissues. The vascular endothelial cell mediates vascular growth, permeability, integrity and interactions with blood cells. In most tissues the endothelium itself is highly specialized to meet the particular needs of the tissue in terms of quality and quantity of incoming and outgoing molecules and messages. The areas covered by Morphogenesis of the Endothelium include the formation of blood vessels in embryonic tissues by vasculogenesis and angiogenesis and the differentiation of endothelium in organs. The contributors are leaders in the field of cardiovascular development, biology and pathology and have written up to date chapters on the mechanisms of blood vessel formation and function in embryos and the adult.

Table of Contents

Tribute	vii
Contributors	ix
Structural, Biochemical and Functional Differentiation of the Vascular Endothelium	1	(22)
Maya Simionescu
Endothelial Fenestrae and Fenestral Diaphragms	23	(20)
W.G. Roberts
G.E. Palade
Adhesion Molecules in Endothelial Cells and their Role in Vascular Morphogenesis	43	(16)
Gianfranco Bazzoni
Elisabetta Dejana
Maria G. Lampugnani
Development of the Vascular Endothelium in Avian Embryos	59	(20)
Francoise Dieterlen-Lievre
Thierry Jaffredo
Arianna Caprioli
Luc Pardanaud
Development of the Heart, Large Vessels and Coronary Vasculature	79	(16)
A.C. Gittenberger-de Groot
R.E. Poelmann
M.C. DeRuiter
The Development of the Retinal Vasculature	95	(14)
Laura E. Benjamin
Rinnat M. Porat
Eli Keshet
Development of the Blood-Brain Barrier	109	(14)
Patricia A. Stewart
Development and Growth of the Pulmonary Microvasculature	123	(30)
Peter H. Burri
Development of the Kidney Vascular System	153	(22)
Barry Robert
Dale R. Abrahamson
Development of the Liver Vascular System	175	(14)
Masabumi Shibuya
Development of the Limb Bud Vascular System	189	(18)
Jorg Wilting
Bodo Christ
Development of the Vascular System in Skeletal Muscle	207	(30)
Josef Stingl
Fay M. Hansen-Smith
Development of the Vascular System in the Corpus Luteum	237	(18)
Hellmut G. Augustin
Development of the Vascular System in the Placenta	255	(22)
Peter Kaufmann
John Kingdom
The Development of the Lymph Node Vasculature	277	(16)
Reina E. Mebius
Irving L. Weissman
Georg Kraal
Index	293