Multiple Sclerosis: Recovery of Function and Neurorehabilitation

by Edited by Jürg Kesselring , Giancarlo Comi , Alan J. Thompson

• ISBN13: 9780521888325
• ISBN10: 0521888328
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-11-22
• Publisher: Cambridge University Press

Summary

Recent developments in basic and applied science have led to better understanding of disease mechanisms and more efficient therapies for multiple sclerosis. The most effective way of managing these patients is through a carefully planned neurorehabilitation programme. The main aims are to reduce disability and handicap and improve functions through effective training, stimulating activity and social participation. As the first text on recovery of function and neurorehabilitation in MS, this book focuses on mechanisms of recovery, application of neuroplasticity to therapeutic interventions, and determination of the efficiency of these interventions. Basic principles of neurorehabilitation in MS are described, as well as techniques for treating specific syndromes which may occur in MS. Written and edited by leading clinicians and researchers, the book achieves an excellent balance between basic science, pathophysiology, and clinical rehabilitation. An essential resource for clinicians and therapists treating patients with multiple sclerosis, neurophysiologists, and health care advisors.

Table of Contents

Preface

Basic Mechanisms

Conduction studies in multiple sclerosis

The physiopathology of multiple sclerosis

Synaptic changes in multiple sclerosis. Do they occur? How effectively can they be analyzed?

Sodium channel expression and function in multiple sclerosis

Basic mechanisms of functional recovery

The adult human oligodendrocyte precursor cell: a key player in myelin repair

Tissue regeneration and repair in multiple sclerosis: the role of neural stem cells

Schwann cells as a potential cell-based therapy for multiple sclerosis

Assessment of Mechanisms and Disease Status

MRI to study white matter damage in multiple sclerosis

MRI to assess gray matter damage in multiple sclerosis

Application of fMRI in multiple sclerosis

fMRI in focal CNS damage

Electrophysiological assessment in multiple sclerosis

fMRI monitoring of therapeutic interventions in multiple sclerosis

Rehabilitation - General Aspects

How to measure the effects of rehabilitation

Value and limits of rehabilitation in multiple sclerosis

Prognosis in neurorehabilitation

Clinical trials to test rehabilitation

Rehabilitation - Sectorial Interventions

Spasticity in multiple sclerosis

Cognitive rehabilitation in multiple sclerosis

Disorders of mood and affect in multiple sclerosis

Bladder dysfunction in multiple sclerosis

Ataxia and imbalance in multiple sclerosis

Sexual problems in multiple sclerosis Per

Bulbar problems in multiple sclerosis

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Index

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