Nanotoxicity From In Vivo and In Vitro Models to Health Risks

by Sahu, Saura C.; Casciano, Daniel A.

• ISBN13: 9780470741375
• ISBN10: 0470741376
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-10-05
• Publisher: Wiley

Summary

Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. This is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences.

Author Biography

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.
Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007), and Toxicogenomics (Wiley, Oct 2008).

Professor Daniel A. Casciano, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Professor Casciano was former director of the US Food and Drug Administration's National Center for Toxicological Research in Jefferson, Arkansas, USA.

Table of Contents

Preface	p. xi
List of Contributors	p. xiii
Acknowledgments	p. xix
Characterization of Nanomaterials for Toxicological Evaluation	p. 1
Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies	p. 29
Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines	p. 41
High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm	p. 61
Application of Zinc Oxide Quantum Dots in Food Safety	p. 81
Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo	p. 97
Evaluation of Toxicity of Nanostructures in Biological Systems	p. 115
Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials	p. 161
Nanoparticles: Is Neurotoxicity a Concern?	p. 171
Hepatotoxic Potential of Nanomaterials	p. 183
Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets	p. 191
Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment	p. 227
Nanotoxicity of Metal Oxide Nanoparticles in Vivo	p. 247
In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity	p. 271
In Vivo and In Vitro Models for Nanotoxicology Testing	p. 279
In Vitro and In Vivo Toxicity Study of Nanoparticles	p. 303
In Vitro and In Vivo Models for Nanotoxicity Testing	p. 335
In Vitro Models for Nanotoxicity Testing	p. 349
In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles	p. 379
Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms	p. 397
Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment	p. 427
Evaluating Strategies For Risk Assessment of Nanomaterials	p. 459
Strategies for Risk Assessment of Nanomaterials	p. 499
Metal Nanoparticle Health Risk Assessment	p. 519
Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products	p. 543
Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials	p. 581
Index	p. 597
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