Nanotoxicity: From In Vivo and In Vitro Models to Health Risks

by Editor: Saura C. Sahu (From Genomics to In Vitro and In Vivo Models); Co-Editor: Daniel A. Casciano (University of Arkansas - Medical Science)

• ISBN13: 9780470747797
• ISBN10: 047074779X
• Format: eBook
• Copyright: 2009-08-01
• Publisher: Wiley

Summary

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials.

Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include:

*general principles of nanotoxicology *applications of nanomaterials *systemic and environmental nanoxicity *models for nanotoxicity testing *mechanisms of nanotoxicity *risk analysis of nanomaterials 

Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Table of Contents

Preface

List of Contributors

Acknowledgments

Characterization of Nanomaterials for Toxicological Evaluation

Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies

Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines

High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm

Application of Zinc Oxide Quantum Dots in Food Safety

Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo

Evaluation of Toxicity of Nanostructures in Biological Systems

Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials

Nanoparticles: Is Neurotoxicity a Concern?

Hepatotoxic Potential of Nanomaterials

Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets

Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment

Nanotoxicity of Metal Oxide Nanoparticles in Vivo

In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity

In Vivo and In Vitro Models for Nanotoxicology Testing

In Vitro and In Vivo Toxicity Study of Nanoparticles

In Vitro and In Vivo Models for Nanotoxicity Testing

In Vitro Models for Nanotoxicity Testing

In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles

Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms

Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment

Evaluating Strategies For Risk Assessment of Nanomaterials

Strategies for Risk Assessment of Nanomaterials

Metal Nanoparticle Health Risk Assessment

Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products

Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials

Index

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