Neurobehavioral Plasticity : Learning, Development, and Response to Brain Insults

by Spear, Norman E.; Spear, Linda P.; Woodruff, Michael L.

• ISBN13: 9780805814255
• ISBN10: 0805814256
• Format: Hardcover
• Copyright: 1995-05-01
• Publisher: Lawrence Erlbau

Summary

This book describes a unique combination of research programs based on a striking variety of hypotheses and procedures directed toward understanding the sources and consequences of neurobehavioral plasticity. This remarkable attribute of the nervous system -- to be pliable and capable of being shaped or formed by natural or artificial sources toward adaptation or maladaptation -- is considered in terms of the neurochemical forces and neuroanatomical structure that has been found to be pivotal for this function. The impetus for this volume was a symposium held to honor Robert L. Isaacson for his scientific and pedagogical achievements as well as his contributions to behavioral neuroscience. Corresponding to his three major research interests, the book is divided into three sections as follows: * the first explores the relationship between the limbic system and behavior, with an emphasis on learning and memory; * the second considers -- through a wide range of approaches -- issues of plasticity in behavior and brain; and * the third deals with neural and chemical determinants of normal and abnormal behavior. This volume is not only a fitting tribute to Isaacson, but also an unusual collection of new evidence, procedures, and theories destined to have significant influence on behavioral neuroscience.

Table of Contents

Preface	p. ix
Yerkes Primate Research Center A Historical Perspective	p. 1
Acknowledgments	p. 11
References	p. 11
Limbic System and Behavior	p. 13
The Hippocampus and Complex Nonspatial Discrimination Is Learning Still """"Not Possible""""?	p. 15
Acknowledgments	p. 31
References	p. 31
Time, Space, and the Hippocampus	p. 33
Acknowledgment	p. 53
References	p. 54
Repairing the Damaged Septohippocampal System	p. 57
References	p. 65
Working Memory for Water-Escape Loci in Rodents	p. 67
References	p. 86
Septal Regulation of the Hippocampal -- Entorhinal Network Memory Formation and Failure	p. 91
References	p. 105
Acknowledgments	p. 105
The Effects of Gangliosides or Nimodipine on Promoting Behavioral Recovery in Rats with Septal Damage	p. 109
References	p. 121
The Septohippocampal Connection Some Behavioral and Anatomical Relationships	p. 123
References	p. 142
Acknowledgments	p. 142
Plasticity in Behavior and Brain	p. 147
The Anatomy of a Memory Modulatory System: From Periphery to Brain	p. 149
Acknowledgments	p. 176
References	p. 177
Structure and Plasticity of the Hebbian Synapse: The Cascading Events for Memory Storage	p. 185
References	p. 198
Functional Recovery Following Damage to the Adult Rat Septohippocampal System	p. 205
References	p. 215
Variables Influencing Behavior After Transplants of Fetal Hippocampus	p. 219
Acknowledgments	p. 232
References	p. 232
Hebbian Plasticity in the Hippocampus Involvement of Protein Phosphorylation and Protein Kinase C	p. 237
References	p. 245
Neuronal Activity Regulates Nerve Growth Factor mRNA Expression in the Adult Rat Hippocampal Formation	p. 249
Acknowledgments	p. 259
References	p. 259
Stress, Stress Hormones, Kindling and Neural Plasticity	p. 263
Acknowledgments	p. 275
References	p. 276
Neural and Chemical Determinants of Normal and Abnormal Behavior	p. 281
Behavioral Plasticity After Teratogenic Alcohol Exposure as Recovery of Function	p. 283
Acknowledgments	p. 301
References	p. 301
Age-Related Differences in Dopamine-Mediated Behaviors Effects of Irreversible Antagonism	p. 311
References	p. 330
Development of Dopamine Systems and Behavior	p. 335
Acknowledgments	p. 345
References	p. 345
Brainstem Influences on Forebrain Processes, Including Memory	p. 349
Acknowledgments	p. 364
References	p. 364
ACTH Neuropeptides, Learning and Creativity	p. 371
Acknowledgment	p. 379
References	p. 379
The Enigma of Reinforcement	p. 381
Appendix	p. 397
References	p. 400
Wandering in Alzheimer's Disease Clinical and Neurobiological Perspectives	p. 405
Acknowledgments	p. 420
Appendix: Modified Caregiver Checklist	p. 420
References	p. 420
Evaluating the Structural Integrity of the Nervous System for Risk Assessment	p. 423
Acknowledgments	p. 435
References	p. 435
Author Index	p. 439
Subject Index	p. 463
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