The Neurobiology of Disease: Contributions from Neuroscience to Clinical Neurology

by Edited by Hugh Bostock , P. A. Kirkwood , A. H. Pullen

• ISBN13: 9780521342384
• ISBN10: 0521342384
• Edition: Revised
• Format: Paperback
• Copyright: 2011-07-14
• Publisher: Cambridge University Press

Summary

Demonstrating the value of interactions between neurology and the basic sciences that underpin it, this volume considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding have been and continue to be made. The coverage boasts an excellent section on the physiology and pathophysiology of central and peripheral nerve fibers and an in-depth view of motor control including the often ignored but vital respiratory movements. Also notable are the chapters on neuronal plasticity, and cell death and axonal regeneration: active areas in neuroscience, where new knowledge will almost certainly revolutionize neurological treatments in years to come.

Table of Contents

Physiology and Pathophysiology of Nerve Fibres

Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve

Molecular anatomy of the node of Ranvier: newer concepts

Delayed rectifier type K+ currents in rabbit and rat axoms and Schwann cells

Axonal signals for potassium channel expression in Schwann cells

Ion channels in human axons

An in vitro model of diabetic neuropathy: electrophysiological studies

Autoimmunity at the neuromuscular junction

The immunopathology and pathophysiology of experimental autoimmune encephalomyelitis

The pathophysiology of human demyelinating neuropathies

Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease

The mechanisms of relapse and remission in multiple sclerosis

Glial transplantation in the treatment of myelin loss or deficiency

Pain: 13. Human nociceptors in health and disease

The sensory consequences of inflammation

Non-voluntary motor unit activity and myofascial pain syndromes

Is there a mechanism for the spinal cord to remember pain?

The neurophysiological basis of pain relief by acupuncture

Control of Central Nervous System Output

Synaptic transduction in neocortical neurones

Cortical circuits, synchronization and seizures

Physiologically induced changes of brain temperature and their effect on extracellular field potentials

Fusimotor patterns of respiratory muscles

Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles

The cerebellum and proprioceptive control of movement

Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control

Central actions of curare and gallamine: implications for reticular reflex myoclonus

The pathophysiology of upper motoneurone disorders

Modulation of hypoglossal motoneurones by thyrotropin releasing hormone and serotonin

Serotonin and central respiratory disorders in the newborn

Are medullary respiratory neurones multipurpose neurones?

Reflex control of expiratory motor output in dogs

Abnormal thoracoabdominal movements in patients with chronic lung disease

Respiratory rhythm and apnoeas in the newborn

Cardiorespiratory interactions during apnoea

Impairment of respiratory control in neurological disease

The respiratory muscles in neurological disease

Development, Survival, Regeneration and Death

Axonal growth and plasticity in the adult nervous system

Target dependence of motoneurones

Rescue of neurones cross-regenerated into foreign targets

Development and repair of neonatal mammalian spinal cord in culture

Selective neuronal vulnerability in motor neurone diseases with reference to sparing of Onuf's nucleus

Excitotoxicity in motor neurone diseases

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