Neurochemistry of Sleep and Wakefulness

by Edited by Jaime Monti , S. R. Pandi-Perumal , Christopher M. Sinton

• ISBN13: 9780521864411
• ISBN10: 0521864410
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-02-18
• Publisher: Cambridge University Press

Summary

Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.

Table of Contents

List of contributors	p. ix
Preface	p. xv
Acknowledgements	p. xvii
Abbreviations	p. xix
The neurochemistry of the states of sleep and wakefulness
Neurochemistry of the preoptic hypothalamic hypnogenic mechanism	p. 3
Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems	p. 23
Rapid eye movement sleep regulation by modulation of the noradrenergic system	p. 59
The influence of neurotransmitters on sleep and wakefulness
Gamma-aminobutyric acid and the regulation of paradoxical, or rapid eye movement, sleep	p. 85
Acetylcholine modulates sleep and wakefulness: a synaptic perspective	p. 109
Histamine in the control of sleep-wakefulness	p. 144
Dopamine in behavioral state control	p. 179
Glutamate neurotransmission and sleep	p. 224
Serotonin and sleep-wake regulation	p. 244
Changing perspectives
Melatonin and its receptors: biological function in circadian sleep-wake regulation	p. 283
Sleep regulatory factors	p. 315
Adenosine and sleep-wake regulation	p. 337
Prostaglandins and the regulation of sleep and wakefulness	p. 363
Neuropeptides and sleep-wake regulation	p. 387
Orexins in sleep and wakefulness: rodent models of narcolepsy-cataplexy	p. 402
The relevance of experimental pharmacology to currently available sleep-wake therapeutics	p. 433
Index	p. 462
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