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The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The book begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Covered next are the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The following section examines the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. The book contains scores of color figures and fully updated chapters; online content packaged exclusively with the Fourth Edition includes detailed animations of neural processes, in-depth supplemental reading, and additional full-color figures and tables.
Irwin B. Levitan, Ph.D., Founding Chair of the Department of Neuroscience at Jefferson Medical College, Thomas Jefferson University
Leonard K. Kaczmarek, Ph.D., Professor of Pharmacology and Cellular and Molecular Physiology, Yale University School of Medicine.
Table of Contents
Preface to the Fourth Edition
I. Introduction 1. Signaling in the Brain 2. Form and Function in Cells of the Brain
II. Electrical Properties of Neurons 3. Electrical Signaling in Neurons 4. Membrane Ion Channels and Ion Currents 5. Ion Channels Are Membrane Proteins 6. Ion Channels, Membrane Ion Currents, and the Action Potential 7. Diversity in the Structure and Function of Ion Channels
III. Intercellular Communication 8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion 9. Synaptic Release of Neurotransmitters 10. Neurotransmitters and Neurohormones 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems 13. Sensory Receptors
IV. Behavior and Plasticity 14. The Birth and Death of a Neuron 15. Neuronal Growth and Trophic Factors 16. Adhesion Molecules and Axon Pathfinding 17. Formation, Maintenance, and Plasticity of Chemical Synapses 18. Intrinsic Neuronal Properties, Neural Networks and Behavior 19. Learning and Memory