Neuroprotective Agents : Fourth International Conference

by Trembly, Bruce; Slikker, William

• ISBN13: 9781573312226
• ISBN10: 1573312223
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-12-01
• Publisher: New York Academy of Sciences

Table of Contents

Preface by The Editors	xi
Part I. Overview of Neuroprotection
U.S. Food and Drug Administration: Future of New Product Strategies and FDA Priorities.	1	(1)
B.A. Schwetz
Neuroprotection against Cerebral Ischemia: A Review of Animal Studies and Correlation with Human Trial Results.	2	(5)
S. Jonas
V. Ayigari
D. Viera
P. Waterman
Questions and Answers	4	(3)
Part II. Clinical Orientation
The Pivotal Role of Iron in NF-kB Activation and Nigrostriatal Dopaminergic Neurodegeneration: Prospects for Neuroprotection in Parkinson's Disease with Iron Chelators.	7	(19)
M.B.H. Youdim
E. Grunblatt
S. Mandel
Hypothermia-Induced Ischemic Tolerance.	26	(16)
Shinsaku Nishio
Zong-Fu Chen
Masatoshi Yunoki
Tomikatsu Toyoda
Matthew Anzivino
Kevin S. Lee
A Double-Blind, Placebo-Controlled Study of the Safety, Tolerability and Pharmacokinetics of CP-101,606 in Patients with a Mild or Moderate Traumatic Brain Injury.	42	(9)
Randall E. Merchant
M. Ross Bullock
Cynthia A. Carmack
Ajit K. Shah
Keith D. Wilner
Grant Ko
Stephen A. Williams
An Open-Label Study of CP-101,606 in Subjects with a Severe Traumatic Head Injury or Spontaneous Intracerebral Hemorrhage.	51	(8)
M. Ross Bullock
Randall E. Merchant
Cynthia A. Carmack
Egon Doppenberg
Ajit K. Shah
Keith D. Wilner
Grant Ko
Stephen A. Williams
Neuroprotective ``Agents'' in Surgery: Secret ``Agent'' Man, or Common ``Agent'' Machine?	59	(20)
Russell J. Andrews
Questions and Answers	73	(6)
Part III. Endogenous Neuroprotectants
Brain Adenosine Receptors as Targets for Therapeutic Intervention in Neurodegenerative Diseases.	79	(14)
Maria P. Abbracchio
Flaminio Cattabeni
Stimulation of Adenosine A3 Receptors in Cerebral Ischemia: Neuronal Death, Recovery, or Both?	93	(14)
Dag K.J.E. Von Lubitz
Wen Ye
Jennifer McClellan
Rick C.-S. Lin
Excitotoxicity, Oxidative Stress, and the Neuroprotective Potential of Melatonin.	107	(12)
S.D. Skaper
M. Floreani
M. Ceccon
L. Facci
P. Giusti
Neuroprotective Role of Melatonin in Methamphetamine- and 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurotoxicity.	119	(1)
Syed F. Ali
Julio L. Martin
M. Dean Black
Yossef Itzhak
Neuroprotective and Cognitive Enhancing Effects of Novel Small Peptides.	120	(1)
A.I. Faden
G. Fox
L. Fan
S. Knoblach
G.L. Araldi
A.P. Kozikowski
Estrogens: Neuroprotective or Neurotoxic?	121	(12)
Andrew C. Scallet
Role of Glycemia in Acute Spinal Cord Injury: Data from a Rat Experimental Model and Clinical Experience.	133	(22)
Francesco Sala
Gaetano Menna
Albino Bricolo
Wise Young
N-Acetylserotonin, Melatonin and Their Derivatives Improve Cognition and Protect against β-Amyloid-Induced Neurotoxicity.	155	(12)
S. Bachurin
G. Oxenkrug
N. Lermontova
A. Afanasiev
B. Beznosko
G. Vankin
E. Shevtzova
T. Mukhina
T. Serkova
Neuroprotective Action of Bilirubin against Oxidative Stress in Primary Hippocampal Cultures.	167	(6)
Sylvain Dore
Solomon H. Snyder
Protective Effect of l-Carnitine in the Neurotoxicity Induced by the Mitochondrial Inhibitor 3-Nitropropionic Acid (3-NPA).	173	(10)
Zbigniew Binienda
John R. Johnson
Alexander A. Tyler-Hashemi
Robert L. Rountree
Philip P. Sapienza
Syed F. Ali
Chung S. Kim
Questions and Answers	179	(4)
Part IV. Mechanisms: Neurodegeneration, Injury, Toxicity
Primary Cultures of Rat Cerebellar Granule Cells as a Model to Study Neuronal 5-Lipoxygenase and FLAP Gene Expression.	183	(8)
Hari Manev
Tolga Uz
Intraneuronal Ion Distribution during Experimental Oxygen/Glucose Deprivation: Routes of Ion Flux as Targets of Neuroprotective Strategies.	191	(13)
Richard M. LoPachin
Matrix Remodeling after Stroke: De Novo Expression of Matrix Proteins and Integrin Receptors.	204	(19)
Julie A. Ellison
Frank C. Barone
Giora Z. Feuerstein
Metallothioneins Attenuate Methylmercury-Induced Neurotoxicity in Cultured Astrocytes and Astrocytoma Cells.	223	(4)
Chang Ping Yao
Jeffrey W. Allen
Michael Aschner
Implication of Poly (ADP-Ribose) Polymerase (PARP) in Neurodegeneration and Brian Energy Metabolism: Decreases in Mouse Brain NAD+ and ATP Caused by MPTP Are Prevented by the PARP Inhibitor Benzamide.	227	(13)
Cristina Cosi
Marc Marien
Neuroprotection against Ischemia by Metabolic Inhibition Revisited: A Comparison of Hypothermia, a Pharmacologic Cocktail and Magnesium Plus Mexiletine.	240	(21)
Kenneth I. Maynard
Alfredo Quinones-Hinojosa
Junaid Y. Malek
Questions and Answers	255	(6)
Part V. Calpain and Neuronal Degeneration
Calpetin and Methylprednisolone Inhibit Apoptosis in Rat Spinal Cord Injury.	261	(9)
Swapan K. Ray
Gloria G. Wilford
Denise C. Matzelle
Edward L. Hogan
Naren L. Banik
Calpastatin Is Upregulated and Acts as a Suicide Substrate to Calpains in Neonatal Rat Hypoxia-Ischemia.	270	(3)
Klas Blomgren
Questions and Answers	272	(1)
Part VI. Glutamate Excitotoxicity: Does It Really Exist?
High Extracellular Glutamate and Neuronal Death in Neurological Disorders: Cause Contribution or Consequence?	273	(14)
Tihomir P. Obrenovitch
Evidence Disputing the Importance of Excitotoxicity in Hippocampal Neuron Death after Experimental Traumatic Brain Injury.	287	(14)
W. Shawn Carbonell
M. Sean Grady
Questions and Answers	299	(2)
Part VII. Neurologic Insults: Mechanisms and Strategies
Neuroprotective Properties of Nitric Oxide.	301	(11)
Chuang C. Chiueh
Neuroprotective Strategies for HIV-1-Associated Neurologic Disease.	312	(2)
Harris A. Gelbard
Changes in mRNA Levels for Heat-Shock/Stress Proteins (Hsp) and a Secretory Vesicle Associated Cysteine-String Protein (Csp1) after Amphetamine (AMPH) Exposure.	314	(16)
John F. Bowyer
David L. Davies
Benzamide, a Poly(ADP-Ribose) Polymerase Inhibitor, Is Neuroprotective against Soman-Induced Seizure-Related Brain Damage.	330	(6)
H.L. Meier
G.P.H. Ballough
J.S. Forster
M.G. Filbert
Central Noradrenergic Neurotoxicity of DSP4 in Mice: Studies on the Neuroprotective Potential of the Poly(ADP-Ribose) Polymerase Inhibitor, Benzamide.	336	(4)
Marc Marien
Cristina Cosi
The Antioxidative Effect of Carboxyfullerenes (C3/D3) on Iron-Induced Oxidative Injury in CNS.	340	(15)
Anya M.Y. Lin
T.-Y. Luh
C.K. Chou
L.T. Ho
Questions and Answers	352	(3)
Part VIII. Growth Factors
Neuregulin Signaling in Brain Injury and in Animal Models of Ischemia.	355	(1)
Mark A. Marchionni
Marc A. Soriano
Ian Murdoch
Elizebeth McCracken
Deborah Dewar
James McCulloch
Protective and Rescuing Abilities of IGF-I and Some Putative Free Radical Scavengers against β-Amyloid-Inducing Toxicity in Neurons.	356	(10)
Sylvain Dore
Stephane Bastianetto
Satyabrata Kar
Remi Quirion
Questions and Answers	365	(1)
Part IX. Spinal Cord Injury: Importance of Inflammatory Response
The Unique Histopathological Responses of the Injured Spinal Cord: Implications for Neuroprotective Therapy.	366	(19)
Lloyd Guth
Ziyin Zhang
Oswald Steward
Part X. Glutamate Receptor Agents
Ion Channel Modulation as the Basis for Neuroprotective Action of MS-153.	385	(15)
Hiroaki Uenishi
Chao-Sheng Huang
Jin-Ho Song
William Marszalec
Toshio Narahashi
Blockade of NAALADase: A Novel Neuroprotective Strategy Based on Limiting Glutamate and Elevating NAAG.	400	(6)
James J. Vornov
Krystyna Wozniak
May Lu
Paul Jackson
Takashi Tsukamoto
Eric Wang
Barbara Slusher
The Low-Affinity, Use-Dependent NMDA Receptor Antagonist AR-R 15896AR: An Update of Progress in Stroke.	406	(15)
Gene C. Palmer
Edward F. Cregan
Paul Bialobok
Simon G. Sydserff
Thomas J. Hudzik
Dennis J. McCarthy
Intracellular Survival Pathways against Glutamate Receptor Agonist Excitotoxicity in Cultured Neurons: Intracellular Calcium Responses.	421	(17)
Ann M. Marini
Yuji Ueda
Carl H. June
Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors.	438	(12)
A.E. Kingston
M.J. O'Neill
A. Bond
V. Bruno
G. Battaglia
F. Nicoletti
J.R. Harris
B.P. Clark
J.A. Monn
D. Lodge
D.D. Schoepp
NPS 1506, A Novel NMDA Receptor Antagonist and Neuroprotectant: Review of Preclinical and Clinical Studies.	450	(12)
Alan L. Mueller
Linda D. Artman
Manuel F. Balandrin
Ellen Brady
Yongwei (Eric) Chien
Eric G. Delmar
Karen George
Allison Kierstead
Thomas B. Marriott
Scott T. Moe
Michael K. Newman
Joanna L. Raszkiewicz
Elizabeth L. Sanguinetti
Bradford C. Van Wagenen
David Wells
Questions and Answers	458	(4)
Part XI. Antioxidants, Cytokines, Unique Animal Model
Peroxynitrite Scavengers for the Acute Treatment of Traumatic Brain Injury.	462	(7)
Edward D. Hall
Nancy C. Kupina
John S. Althaus
Regional Cytokine, Cytokine Receptor and Neuropeptide mRNA Changes Associated with Behavioral and Neuroanatomical Abnormalities in Persistent, Noninflammatory Virus Infection of Neonatal Rats.	469	(1)
Carlos R. Plata-Salaman
Sergey E. Ilyin
Dave Gayle
Anna Romanovitch
Kathryn M. Carbone
Development of a Nonhuman Primate Model for Studying the Consequences of Long-Term Neuroprotectant Administration on Complex Brain Functions in Developing Animals.	470	(1)
Merle G. Paule
E. Jon Popke
Edwin Pearson
Tim Hammond
Melatonin as a Pharmacological Agent against Neuronal Loss in Experimental Models of Huntington's Disease, Alzheimer's Disease and Parkinsonism.	471	(18)
Russel J. Reiter
Javier Cabrera
Rosa M. Sainz
Juan Carlos Mayo
Lucien C. Manchester
Dun-Xian Tan
Questions and Answers	486	(3)
Part XII. Drugs of Abuse
The Regulation of Cerebral Blood Flow during Intravenous Cocaine Administration in Cocaine Abusers.	489	(6)
Ronald I. Herning
Warren Better
Richard Nelson
David Gorelick
Jean L. Cadet
Time Course of Brain Temperature and Caudate/Putamen Microdialysate Levels of Amphetamine and Dopamine in Rats after Multiple Doses of d-Amphetamine.	495	(10)
Peter Clausing
John F. Bowyer
Neuroprotective Effects of HU-211 on Brain Damage Resulting from Soman-Induced Seizures.	505	(10)
Margaret G. Filbert
Jeffry S. Forster
C. Dahlem Smith
Gerald P.H. Ballough
Abuse Liability Assessment of Neuroprotectants.	515	(14)
Michael Klein
Silvia Calderon
BeLinda Hayes
Questions and Answers	526	(3)
Part XIII. Conference Summary
The Future of Neuroprotection.	529	(6)
W. Slikker
M. Youdim
Gene C. Palmer
E. Hall
C. Williams
B. Trembly
Index of Contributors	535