Nicotinic Receptors in the Nervous System

by Levin; Edward D.

• ISBN13: 9780849323867
• ISBN10: 084932386X
• Format: Hardcover
• Copyright: 2001-08-29
• Publisher: CRC Press

Summary

Nicotine research has been conducted for the better part of a century, but with the discovery of the relationship of nicotinic systems to Alzheimer's disease, the differentiation of nicotinic receptor subtypes, and the development of novel nicotinic ligands, the field of nicotine research has exploded. This book will provide you reference to the latest research methods and findings concerning nicotinic neural systems.Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of cutting-edge research concerning neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, this book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments.Within the next several years, it is very promising that clinical research will support the use of nicotinic treatments for addiction, pain, and cognitive and motor dysfunction. Nicotinic Receptors in the Nervous System provides you with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.

Table of Contents

Section 1
Some Methods for Studies of Nicotinic Acetylcholine Receptor Pharmacology	3	(26)
Ronald J. Lukas
John D. Fryer
J. Brek Eaton
Cynthia L. Gentry
Presynaptic Nicotinic Acetylcholine Receptors: Subtypes Mediating Neurotransmitter Release	29	(22)
Susan Wonnacott
Adrian Mogg
Amy Bradley
Ian W. Jones
Effects of Nicotine on Dopaminergic Neurotransmission	51	(30)
Peter P. Rowell
Nicotinic Receptors in the Periphery	81	(32)
Susan Jones
Hao Lo
Sidney A. Simon
Section 2
Nicotinic Cholinergic Receptors as Targets in Pain Control	113	(30)
M. Imad Damaj
Christopher M. Flores
Mouse Models to Evaluate Genetic Influences on Responses to Nicotine	143	(24)
Michael J. Marks
Allan C. Collins
Nicotinic Involvement in Cognitive Function of Rats	167	(12)
Edward D. Levin
Amir H. Rezvani
Nicotine and Cognition in Young and Aged Nonhuman Primates	179	(20)
Jerry J. Buccafusco
Alvin V. Terry
Neuroscience Research with Nicotine Self-Administration	199	(18)
William A. Corrigall
Section 3
Evaluation of Pharmacologic Treatments for Smoking Cessation	217	(10)
Jed E. Rose
Nicotine and Schizophrenia	227	(8)
Joseph P. McEvoy
Nicotinic Medications and Tourette's Disorder	235	(16)
R. Douglas Shytle
Archie A. Silver
Mary Newman
Berney J. Wilkinson
Paul R. Sanberg
Nicotine Effects on Attention Deficit Hyperactivity Disorder	251	(10)
Edward D. Levin
Clinical Methodologies in the Examination of Nicotinic Effects on Cognition	261	(20)
Alexandra Potter
Paul A. Newhouse
Section 4
Nicotinic Systems: An Integrated Approach	281	(2)
Edward D. Levin
Index	283