Nitroalkanes Synthesis, Reactivity, and Applications

by Ballini, Roberto; Palmieri, Alessandro

• ISBN13: 9783527347452
• ISBN10: 3527347453
• Edition: 1st
• Format: Hardcover
• Copyright: 2021-04-26
• Publisher: Wiley-VCH

Summary

Discover a comprehensive exploration of recent progress in the preparation of nitroalkanes from two leading voices in the field

Nitroalkanes: Synthesis, Reactivity, and Applications delivers a thorough summary of the importance of nitroalkanes in organic synthesis. The book covers their preparation, transformation into other functional groups, like carbonyls and amines, and their use in the formation of single carbon-carbon or double carbon-carbon bonds. The distinguished authors have included chapters on acyclic and cyclic alpha-nitro ketones as well as the synthesis of cyclopropanes and spiro ketals.

The book provides treatments of the application of nitroalkanes for the synthesis of important heterocycles, poly-functionalized structures, natural products, and compounds of biological and pharmaceutical interest. A one-stop resource in a topic that hasn???t been fully addressed by any other book in decades, this book covers the most important synthetic routes toward nitroalkanes.

Readers will also benefit from the inclusion of:

A thorough introduction to the synthesis of nitroalkanes, as well as the transformation of the nitro group into other functionalities

An exploration of the formation of C-C single bonds, C=C double bonds, and the breaking of C₃C bonds from cyclic alpha-nitro ketones

Discussions of acyclic alpha-nitro ketones, nitroalkanes as precursors of cyclopropanes, and the synthesis of spiro ketals

An examination of the preparation and synthetic applications of 1,3-Dinitroalkanes

Perfect for organic chemists, natural products chemists, and catalytic chemists, Nitroalkanes: Synthesis, Reactivity, and Applications will also earn a place in the libraries of medicinal chemists seeking a one-stop resource for the most recent developments in the preparation of nitroalkanes, their functionalization, and their applications.

Author Biography

Roberto Ballini is Professor of Organic Chemistry at the University of Camerino, Italy. His research is mainly dedicated to organic synthesis, with particular emphasis on aliphatic nitro compounds. He has published more than 250 articles and edited two books.

Alessandro Palmieri is Associate Professor at the University of Camerino, Italy. He develops eco-friendly processes for the formation of C-C and C-X bonds, and flow chemical protocols for the synthesis of fine chemicals. He is co-author of 100 publications.

Table of Contents

Synthesis of Nitroalkanes
Transformation of the Nitro Group into Other Functionalities
Formation of C-C Single Bonds
Formation of C=C Double Bonds
Breaking of C,C Bonds from Cyclic Alpha-Nitro Ketones
Acyclic Alpha-Nitro Ketones
Nitroalkanes as Precursors of Cyclopropanes
Synthesis of Spiro Ketals
Preparation and Synthetic Applications of 1,3-Dinitroalkanes
Synthesis of Fine Chemicals from Nitroalkanes