The Nucleus

by Misteli, Tom; Spector, David L.

• ISBN13: 9780879698942
• ISBN10: 0879698942
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-11-22
• Publisher: Cold Spring Harbor Laboratory Press

Summary

The nucleus of a cell contains its DNA and is the site where DNA replication, transcription, and RNA processing take place. Nuclei have many domains but lack the membrane-bound organelles characteristic of the cytoplasm. Instead, nuclear bodies appear to dynamically self-organize, assembling and disassembling according to the functional demands of the cell. Written and edited by experts in the field, this volume includes contributions discussing the relationship between nuclear structure and function, the various nuclear bodies that have been identified, and the organization of the nuclear lamina and nuclear pore complex. Including a historical introduction to the field and discussion of the numerous pathological conditions involving disruption of nuclear structure and function, this volume is essential reading for all molecular and cell biologists, as well as pathologists interested in the role of nuclear architecture in disease.

Author Biography

Tom Misteli, National Cancer Institute; David L. Spector, Cold Spring Harbor Laboratory

Table of Contents

Preface	p. ix
Overview
The Nucleus Introduced	p. 1
The Nuclear Periphery
The Nuclear Envelope	p. 17
Nuclear Lamins	p. 33
Lamin-binding Proteins	p. 55
The Nuclear Pore Complex and Nuclear Transport	p. 73
Chromosomes & Chromatin
Chromosome Territories	p. 93
Gene Positioning	p. 115
Chromatin Higher-order Structure and Dynamics	p. 133
Nuclear Organization and Dosage Compensation	p. 159
The Budding Yeast Nucleus	p. 175
Nuclear Functions of Actin	p. 195
Nuclear Bodies
The Nucleolus	p. 209
Nuclear Speckles	p. 225
The Cajal Body and Histone Locus Body	p. 237
PML Nuclear Bodies	p. 249
The Perinucleolar Compartment	p. 267
Paraspeckles	p. 277
Nuclear Stress Bodies	p. 291
Orphan Nuclear Bodies	p. 303
Biogenesis of Nuclear Bodies	p. 315
Functional Organization
Organization of Transcription	p. 331
Organization of DNA Replication	p. 347
DNA Damage Response	p. 361
RNA Processing and Export	p. 381
Nuclear Architecture in Differentiation and Disease
Diseases of the Nuclear Envelope	p. 401
Higher-order Genome Organization in Human Disease	p. 419
Nuclear Ataxias	p. 437
Developments in RNA Splicing and Disease	p. 449
Appendix
Tables of Data on the Nucleus: (Adapted by kind permission of Federation of American Societies for Experimental Biology [FASEB] from Biological Handbooks. I. Cell Biology [Altman P.L. and Katz DD; 1976], Bethesda, Maryland.)	p. 463
Index	p. 507
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