Nutrition and Chemical Toxicity

by Ioannides, Costas

• ISBN13: 9780471974536
• ISBN10: 0471974536
• Edition: 1st
• Format: Hardcover
• Copyright: 1998-11-02
• Publisher: Wiley

Summary

Current Toxicology Series Series Editors Diana Anderson BIBRA Toxicology International, Surrey, UK Michael D Waters Consultant, Chapel Hill, NC, USA Timothy C Marrs Department of Health, London, UK Nutrition and Chemical Toxicity Edited by Costas Ioannides, University of Surrey, Guildford, UK An enormous amount of research is currently devoted to evaluating the role of nutrition in the aetiology of major human diseases and to clarifying the underlying mechanisms. This resurgent interest reflects the realisation that carcinogens may be generated during the normal cooking of food and that they may play a role in human carcinogenesis. Moreover, during the last decade it has become apparent that naturally occurring chemicals in food, primarily of plant origin, can afford effective protection against human cancer and heart disease. As a result, the need for up-to-date information in this subject area has never been greater. Nutrition and Chemical Toxicity deals in depth with the various toxicants found in food including naturally occurring chemicals, fungal contaminants, products of the cooking process and allergens. Other chapters focus on nutritional modulation of cytochromes P450; interactions between drugs and diet; glutathione, sulphur aminoacids and chemical detoxication; modulation of the carcinogenic response by caloric restriction; and lipotropes and chemical carcinogenesis. Further contributions discuss the expression of chemical toxicity in vitamin deficiency and supplementation; safety evaluation of vitamins and minerals; naturally occurring organosulphur compounds as potential anticarcinogens; cancer chemoprevention by tea polyphenols; and animal diets in safety evaluation studies. This timely book is essential reading for professionals involved in cancer research and the safety evaluation of chemicals, food scientists and toxicologists, nutritionists and those involved with food regulation.

Author Biography

Costas Ioannides is the editor of Nutrition and Chemical Toxicity, published by Wiley.

Table of Contents

Contributors	vii	(4)
Foreword	xi
1 Toxicants in Food: Naturally Occurring	1	(28)
Hideki Mori
Takuji Tanaka
Iwao Hirono
2 Toxicants in Food: Fungal Contaminants	29	(30)
Jia-Sheng Wang
Thomas W Kensler
John D Groopman
3 Toxicants in Food: Generated During Cooking	59	(22)
Kerstin I Skog
Margaretha Jagerstad
4 Toxicants in Food: Food Allergens	81	(34)
Gerald Reese
Samuel B Lehrer
5 Nutritional Modulation of Cytochromes P450	115	(46)
Costas Ioannides
6 Interactions between Drugs and Diet	161	(22)
John A Thomas
W Wayne Stargel
Christian Tschanz
7 Glutathione, Sulphur Amino Acids and Chemical Detoxication	183	(18)
Tammy M Bray
Emily Ho
Mark A Levy
8 Modulation of the Carcinogenic Response by Caloric Restriction	201	(18)
Angelo Turturro
William T Allaben
Julian E Leakey
Ronald W Hart
9 Lipotropes and Chemical Carcinogenesis	219	(18)
Emmanuel Farber
Amiya K Ghoshal
10 Expression of Chemical Toxicity in Vitamin Deficiency and Supplementation	237	(20)
Gary Williamson
11 Safety Evaluation of Vitamins and Minerals	257	(28)
John N Hathcock
12 Naturally Occurring Organosulphur Compounds as Potential Anticarcinogens	285	(16)
Hideki Mori
Akiyoshi Nishikawa
13 Cancer Chemoprevention by Tea Polyphenols	301	(44)
Nihal Ahmad
Santosh K Katiyar
Hasan Mukhtar
14 Animal Diets in Safety Evaluation Studies	345	(30)
Ghanta N Rao
Joseph J Knapka
Index	375