Nutrition and Gene Expression

by Berdanier, Carolyn D.; Hargrove, James L.

• ISBN13: 9780849369612
• ISBN10: 0849369614
• Format: Hardcover
• Copyright: 1992-12-01
• Publisher: CRC Pr I Llc

Summary

Nutrition and Gene Expression is devoted to exploring the tissue-specific and developmental aspects of the interaction between nutrients and the genome. The book discusses chemical sensitivity in relation to the ability of cells to detect nutrients; reviews the means by which lower organisms respond to nutrients; and provides examples on how each of the classes of nutrients affects genetic transcription, mRNA translation or stability. The receptor-mediated actions of vitamin D and retinoic acid on gene expression are discussed, including the case of bone formation and dissolution. Other important topics covered in the volume include newly discovered effects of fatty acids on regulating gene expression, the effects of diet on mRNA editing, the interplay between dietary carbohydrates and proteins in regulating metabolism of liver cells, the effects of metal ions on protein synthesis, and much more.Nutrition and Gene Expression is an important reference for nutritionists, physiologists, biochemists, clinical nutritionists, pharmaceutical researchers, geneticists, and food scientists.

Table of Contents

Nutrient Receptors and Gene Expression	p. 1
Lactose Intolerance and Regulation of Small Intestinal Lactase Activity	p. 23
Regulation of Gastrointestinal Lipase Gene Expression by Dietary Lipids	p. 55
Nutritional Control of Gastrointestinal Hormone Gene Expression	p. 91
Calcium Homeostasis, Endoplasmic Reticular Function, and the Regulation of mRNA Translation in Mammalian Cells	p. 117
Tissue-Specific Regulation of Glucokinase	p. 143
Dietary and Hormonal Regulation of L-Type Pyruvate Kinase Gene Expression	p. 169
Glucose-6-Phosphate Dehydrogenase: Diet and Hormonal Influences on De Novo Enzyme Synthesis	p. 187
Nutritional and Hormonal Regulation of Genes Encoding Enzymes Involved in Fat Synthesis	p. 207
Regulation of Hepatic Gene Expression by Dietary Fats: A Unique Role for Polyunsaturated Fatty Acids	p. 227
Dietary Fat, Gene Expression, and Carcinogenesis	p. 247
Regulation of Acetyl CoA Carboxylase and Gene Expression	p. 269
Apolipoprotein B mRNA Editing	p. 297
Regulation of the 68 kDa Hepatic Carnitine Palmitoyltransferase	p. 319
Long-Term Regulation of Hepatic Glutaminase and the Urea Cycle Enzymes	p. 335
Effects of Dietary Protein on Gene Expression	p. 353
Vitamin D-Dependent Calcium Binding Protein, Calbindin-D: Regulation of Gene Expression	p. 377
Vitamin D Regulation of Osteoblast Growth and Differentation	p. 391
Retinoic Acid Regulation of Gene Expression in Adipocytes	p. 431
The Role of Vitamin K in Clotting Factor Biosynthesis	p. 455
Role of Ascorbate in Regulating the Collagen Pathway	p. 483
Dietary Regulation of Metallothionein Expression	p. 507
Iron-Dependent Regulation of Ferritin Synthesis	p. 525
Vitamin B[subscript 6] Modulation of Steroid Induced Gene Expression	p. 547
Index	p. 569
Table of Contents provided by Blackwell. All Rights Reserved.