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This is the 2nd edition with a publication date of 12/31/2008.
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Organic Synthesis: The Disconnection Approach is the long-awaited second edition of a classic textbook; the first to provide a structured course in retrosynthesis- now an important technique used by generations of organic chemists. Now fully revised and updated with a modern look, 25 years of advances in organic synthesis are reflected with the addition of new examples and synthetic pathways. Additional material has been added to take the student to the level required by the bestselling sequel, "Organic Synthesis: Strategy and Control" and the later chapters have extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.
Table of Contents
|General References||p. xi|
|The Disconnection Approach||p. 1|
|Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds||p. 7|
|Strategy I: The Order of Events||p. 17|
|One-Group C-X Disconnections||p. 23|
|Strategy II: Chemoselectivity||p. 29|
|Two-Group C-X Disconnections||p. 35|
|Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy||p. 45|
|Amine Synthesis||p. 53|
|Strategy IV: Protecting Groups||p. 61|
|One Group C-C Disconnections I: Alcohols||p. 69|
|General Strategy A: Choosing a Disconnection||p. 77|
|Strategy V: Stereoselectivity A||p. 83|
|One Group C-C Disconnections II: Carbonyl Compounds||p. 93|
|Strategy VI: Regioselectivity||p. 101|
|Alkene Synthesis||p. 107|
|Strategy VII: Use of Acetylenes (Alkynes)||p. 115|
|Two-Group C-C Disconnections I: Diels-Alder Reactions||p. 121|
|Strategy VIII: Introduction to Carbonyl Condensations||p. 129|
|Two-Group C-C Disconnections II: 1,3-Difunctionalised Compounds||p. 133|
|Strategy IX: Control in Carbonyl Condensations||p. 139|
|Two-Group C-C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation||p. 151|
|Strategy X: Aliphatic Nitro Compounds in Synthesis||p. 161|
|Two-Group Disconnections IV: 1,2-Difunctionalised Compounds||p. 167|
|Strategy XI: Radical Reactions in Synthesis||p. 177|
|Two-Group Disconnections V: 1,4-Difunctionalised Compounds||p. 185|
|Strategy XII: Reconnection||p. 193|
|Two-Group C-C Disconnections VI: 1,6-diCarbonyl Compounds||p. 199|
|General Strategy B: Strategy of Carbonyl Disconnections||p. 207|
|Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles||p. 217|
|Three-Membered Rings||p. 229|
|Strategy XIV: Rearrangements in Synthesis||p. 237|
|Four-Membered Rings: Photochemistry in Synthesis||p. 245|
|Strategy XV: The Use of Ketenes in Synthesis||p. 251|
|Five-Membered Rings||p. 255|
|Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings||p. 261|
|Six-Membered Rings||p. 269|
|General Strategy C: Strategy of Ring Synthesis||p. 279|
|Strategy XVII: Stereoselectivity B||p. 289|
|Aromatic Heterocycles||p. 301|
|General Strategy D: Advanced Strategy||p. 313|
|Table of Contents provided by Ingram. All Rights Reserved.|