Organic Synthetic Methods

by Hanson, James R.; Davies, A. G.; Phillips, David; Abel, E. W.

• ISBN13: 9780854046829
• ISBN10: 0854046828
• Format: Paperback
• Copyright: 2002-10-24
• Publisher: Royal Society of Chemistry

Summary

Synthesis is one of the major endeavours of the organic chemist, and the design of a successful synthesis requires a sound knowledge of functional group chemistry, stereochemistry and organic reaction mechanisms. Organic Synthetic Methods introduces the major methods of creating carbon-carbon and carbon-nitrogen bonds, along with functional group interconversions (oxidation, reduction, halogenation). The use of protecting groups and solid-phase methods are also discussed. The analysis of the structure of a target molecule, in terms of the structural consequences of synthetic reactions, is introduced to enable the student to identify key dissections and building blocks and hence develop a suitable synthetic method. Examples of the synthesis of labelled compounds are also provided. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major new series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.

Table of Contents

Introduction	p. 1
Organometallic and Ylide Methods of Carbon-Carbon Bond Formation	p. 9
Carbonyl Activation and Enolate Chemistry in Carbon-Carbon Bond Formation	p. 32
Carbocations in Synthesis	p. 54
Free Radical and Pericyclic Reactions in the Formation of Carbon-Carbon Bonds	p. 64
Methods of Making Carbon-Nitrogen Bonds	p. 78
Functional Group Transformations	p. 96
Protecting Groups	p. 126
Some Examples of Total Syntheses	p. 142
Further Reading	p. 153
Answers to Problems	p. 157
Subject Index	p. 173
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