Oxford Textbook of Endocrinology and Diabetes 3e

by Wass, John; Arlt, Wiebke; Semple, Robert

• ISBN13: 9780198870197
• ISBN10: 0198870191
• Edition: 3rd
• Format: Hardcover
• Copyright: 2022-06-22
• Publisher: Oxford University Press

Author Biography

John Wass, Professor of Endocrinology, Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford, UK,Wiebke Arlt, Director of the Institute of Metabolism and Systems Research, Institute of Metabolism and Systems Research, University of Birmingham; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK,Robert Semple, Professor of Translational Molecular Medicine, University of Edinburgh Centre for Cardiovascular Science, Queen's Medical Institute, Edinburgh, UK

Professor Wass is a Professor of Endocrinology at Oxford University and was the Head of the Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford, UK until 2011. From 1989 he was Professor of Clinical Endocrinology and Sub-Dean, University of London at Bart's. He founded and ran the Oxfordshire Osteoporosis Service in 1995. John Wass is currently the Clinical Reference Group Chair for Endocrinology in the UK.
He was President of the European Federation of Endocrine Societies from 2001-2203 and was Chairman of the Society for Endocrinology (2006-2009). He was awarded the Distinguished Physician of the Year Award by the American Endocrine Society, the first non-American to ever receive this award Elected Academic Vice President of the Royal College of Physicians London in 2012 he has chaired the Royal College of Physicians Working Party 'Action on Obesity: Comprehensive Care for All' published in January 2013.

Wiebke Arlt qualified at the University of Cologne in 1990. She trained in Endocrinology from 1994 to 1998 under the auspices of Professor Bruno Allolio at the University Hospital W?rzburg, Germany. She then spent two years in the Molecular Endocrinology Lab of the Department of Paediatrics at the University of California in San Francisco (UCSF), hosted by Walter Miller. Following her return to Wuerzburg in 2001 she was appointed Consultant Endocrinologist. She obtained a prestigious Heisenberg Fellowship from the German Research Council and moved to Birmingham in October 2002. In 2004, she obtained an MRC Senior Clinical Fellowship and was appointed Senior Lecturer at the University of Birmingham. Promotion to Chair of Medicine in 2006 and to Head of the Centre for Endocrinology, Diabetes and Metabolism in 2008. She was awarded the William Withering Chair of Medicine in 2014 and appointed as Director of the newly founded Institute of Metabolism and Systems Research in 2015.

Professor Semple is an endocrinologist based at the University of Edinburgh, where he is also Dean of Postgraduate Research for the College of Medicine and Veterinary Medicine. His interests include insulin resistance, diabetes, hypoglycaemia and mosaic growth disorders, in each of which he engages in fundamental molecular and cellular research, translational studies, and clinical practice.

Table of Contents

1. Principles of basic and clinical endocrinology
1.1. Endocrine Practice Fundamentals, Lynn Loriaux
1.2. Hormones and receptors: fundamental considerations, John W. Funder
1.3. Molecular aspects of hormonal regulation, Ken Siddle and Gemma Brierley
1.4. Endocrinology and evolution: lessons from comparative endocrinology, Janine A. Danks and Samantha J. Richardson
1.5. Hormones Across the Lifespan, James Gibney, Indi Banerjee, and Ken Ho
1.6. Pituitary assessment strategy, Brian Keevil, Peter Trainer, and William Drake
1.7. Endocrine autoimmunity, Simon Pearce and Catherine Owen
1.8. Common Features of Endocrine Tumours, Jerome Bertherat, Anne Jouinot, and Fid?line Bonnet-Serrano
1.9. Genetic Aspects of Endocrine Disease, Trevor Cole
1.10. Environmental Influences on Endocrine Disease, George Mastorakos, Markella Nezi, Djuro Macut, and Maria Papagianni
1.11. Endocrinology, sleep and circadian rhythms, Georg Brabant and H. Oster
1.12. Principles of Hormone replacement, Richard Ross
1.13. Prevention in endocrinology, Jonathan Valabhji and Rochan Agha-Jaffar
2. Pituitary and hypothalamic diseases
2.1. Functional anatomy of the hypothalamus and pituitary, John Morris
2.2. The neurohypophysis, Stephen G. Ball
2.3. Aetiology, pathogenesis, and management of disease of the pituitary
2.3.1. Development of the pituitary and genetic forms of hypopituitarism, Mehul T. Dattani and Louise C. Gregory
2.3.2. Molecular pathogenesis of pituitary tumours, Shlomo Melmed
2.3.3. Histopathology of pituitary tumours, Luis Syro, Kalman Kovacs, and Fabio Rotondo
2.3.4. Imaging of the pituitary, Jean-Francois Bonneville, Sonia Nagi, and Iulia Potorac
2.3.5. Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes, Miles J. Levy, Ragini Bhake, and Narendra Reddy
2.3.6. Adult growth hormone deficiency, Jens J?rgensen
2.3.7. Surgery of pituitary tumours, Edward R. Laws Jr, David L. Penn, and Caroline S. Repetti
2.3.8. Pituitary radiotherapy, Naomi Fersht and Francesca Solda
2.3.9. Prolactinomas and hyperprolactinaemia (including macroprolactinaemia), Nicholas Tritos and Anne Klibanski
2.3.10. Acromegaly, John Wass, Peter J. Trainer, and M?rta Korbonits
2.3.11. Clinically nonfunctioning pituitary tumours and gonadotropinomas, Nienke Biermasz and Wouter R. van Furth
2.3.12. Thyrotropinomas, Mark Gurnell, Olympia Koulouri, and Waiel Bashari
2.3.13. Pituitary carcinoma, Ann McCormack
2.3.14. Pituitary incidentalomas, Niki Karavitaki, Shu Teng Chai, and Shahzada Ahmed
2.4. Aetiology, pathogenesis, and management of diseases of the hypothalamus
2.4.1. Hypothalamic dysfunction (hypothalamic syndromes), Mehul Dattani, Hoong-Wei Gan, and Manuela Cerbone
2.4.2. Craniopharyngiomas, Niki Karavitaki
2.4.3. Perisellar tumours including cysts, hamartomas, and vascular tumours, J?rgen Honegger, Ulrike Ernemann, and Rudi Beschorner
2.4.4. Lymphocytic hypophysitis and other inflammatory conditions of the pituitary, Mark E. Molitch and Jelena Kravarusic
2.5. Pineal physiology and pathophysiology, including pineal tumours, Susan M Webb, Anna Aulinas, Cristina Colom, and Jos? Barahona
3. The Thyroid
3.1. Evaluation of the thyroid patient
3.1.1. The history and iconography relating to the thyroid gland, Robert Volp? and Clark Sawin
3.1.2. Biosynthesis, transport, metabolism, and actions of thyroid hormones, W. Edward Visser
3.1.3. Clinical assessment of the thyroid patient, Inge B?low Pedersen and Stig Andersen
3.1.4. Thyroid function tests and the effects of drugs, Ulla Feldt-Rasmussen
3.1.5. Nonthyroidal illness syndrome, Robin P. Peeters and Anita Boelen
3.1.6. Thyroid imaging: nuclear medicine techniques, Steen Bonnema and Laszlo Heged?s
3.1.7. Thyroid imaging: nonisotopic techniques, Laszlo Heged?s and Finn N. Bennedb?k
3.1.8. Epidemiology of thyroid disease and swelling, Mark P. J. Vanderpump
3.2. Aetiology of thyroid disorders
3.2.1. The complex genetics of thyroid disease, Terry Davies, Francesca Menconi, and Yaron Tomer
3.2.2. Environmental factors, Josef K?hrle
3.2.3. Iodine deficiency disorders, Michael B. Zimmermann
3.2.4. Radiation-induced thyroid disease, Shunichi Yamashita, Furio Pacini, and Rossella Elisei
3.2.5. Autoimmune thyroid disease, Anthony P. Weetman
3.2.6. Thyroiditis, Elizabeth N. Pearce and Alan Farwell
3.3. Thyrotoxicosis and related disorders
3.3.1. Clinical assessment and systemic manifestations of thyrotoxicosis, Claudio Marcocci and Filomena Cetani
3.3.2. Thyrotoxic periodic paralysis, Annie W. C. Kung and C.L. Cheung
3.3.3. Thyrotoxic storm, Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska
3.3.4. Subclinical hyperthyroidism, Simon Pearce
3.3.5. Causes and laboratory investigations of thyrotoxicosis, Francesco Latrofa and Paolo Vitti
3.3.6. Anti-thyroid drug treatment for thyrotoxicosis, Luigi Bartalena
3.3.7. Radio-iodine treatment of hyperthyroidism, Markus Luster and Michael Lassmann
3.3.8. Surgery for thyrotoxicosis, Nancy Dugal Perrier, Orlo Clark, and Sarah B. Fisher
3.3.9. Management of Graves hyperthyroidism, Jacques Orgiazzi
3.3.10. Graves orbitopathy and dermopathy, Wilmar M. Wiersinga
3.3.11. Management of toxic multinodular goitre and toxic adenoma, Dagmar F?hrer and Holger J?schke
3.3.12. Management of thyrotoxicosis without hyperthyroidism, Wilmar M. Wiersinga
3.4. Hypothyroidism
3.4.1. Clinical assessment and systemic manifestations of hypothyroidism, Massimo Tonacchera and Luca Chiovato
3.4.2. Causes and laboratory investigation of hypothyroidism, Ferruccio Santini
3.4.3. Myxoedema coma, Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska
3.4.4. Subclinical hypothyroidism, Bijay Vaidya and Chantal Daumerie
3.4.5. Syndromes of Resistance to Thyroid Hormone, Mark Gurnell, Carla Moran, and V. K. Chatterjee
3.4.6. Treatment of hypothyroidism, Birte Nygaard
3.5. Thyroid lumps
3.5.1. Pathogenesis of nontoxic goitre, Dagmar F?hrer and Holger J?schke
3.5.2. Management of nontoxic multinodular goitre, Hans Graf and Gilberto Paz Filho
3.5.3. Management of the single thyroid nodule, Laszlo Heged?s and Finn N. Bennedb?k
3.5.4. Pathogenesis of thyroid cancer, Massimo Santoro, Barbara Jarzab, Jolanta Krajewska, and Dagmara Rusinek
3.5.5. Pathology of thyroid cancer, Fulvio Basolo and Clara Ugolini
3.5.6. Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma, Corin Badiu and Ruxandra Dobrescu
3.5.7. Medullary thyroid carcinoma, Friedhelm Raue and Karin Frank-Raue
4. Parathyroid, calcium, and bone metabolism
4.1. Parathyroid anatomy, hormone synthesis, secretion, action, and receptors, David Goltzman and Geoffrey N. Hendy
4.2. Hypercalcaemia, Claudio Marcocci, Federica Saponaro, and Filomena Cetani
4.3. Primary hyperparathyroidism, John P. Bilezikian
4.4. Familial Hypocalciuric Hypercalcemia Types 1-3 and Neonatal Severe Primary Hyperparathyroidism, Dolores Shoback and Muriel Babey
4.5. Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism, Rajesh Thakker, Bart Clarke, and Fadil M. Hannan
4.6. Bones and the Kidney, Paul Miller, Irinel Stanciu, and Michael Pazianas
4.7. Hypercalcaemic and hypocalcaemic syndromes in children, Laleh Ardeshirpour, Thomas O. Carpenter, and Cemre Robinson
4.8. Osteoporosis, Richard Eastell
4.9. Thyroid disorders and bone disease, Graham R. Williams, J. H. Duncan Bassett, Bernard Freudenthal, and Laura M. Watts
4.10. Paget s disease of bone, Socrates E. Papapoulos
4.11. Rickets and osteomalacia (acquired and heritable forms), Michael P. Whyte
4.12. Glucocorticoid-induced osteoporosis, Gherardo Mazziotti, Ernesto Canalis, and John P. Bilezikian
5. The adrenal gland and endocrine hypertension
5.1. Adrenal imaging, Peter Guest
5.2. Adrenal surgery, Fausto Palazzo and Radu Mihai
5.3. Adrenal incidentaloma, Irina Bancos, Massimo Terzolo, and Wiebke Arlt
5.4. Adrenocortical cancer, J?r?me Bertherat, Rossella Lib?, and Anne Jouinot
5.5.1. Genetics of phaeochromocytomas, paragangliomas, and neuroblastoma, Eamonn R. Maher and Ruth T Casey
5.5.2. Management of phaeochromocytoma and paragagnlioma, Henri Timmers
5.6.1. Genetics of primary aldosteronism and other steroid-related causes of endocrine hypertension, Maria Christina Zennaro, Fabio Fernandes-Rosa, and Sheerazed Boulkroun
5.6.2. Management of primary aldosteronism, Morris Brown and Will Drake
5.7. Cushing s syndrome, John Newell-Price
5.8.1. Genetics of Adrenal Insufficiency, Li Chan and Shwetha Ramachandrappa
5.8.2. Management of Adrenal Insufficiency, Wiebke Arlt
5.9.1. Genetics of congenital adrenal hyperplasia, Nils P. Krone
5.9.2. Modern management of congenital adrenal hyperplasia and prospects for the future, Richard J. Auchus
6. Neuroendocrine tumours and genetic disorders
6.1. Overview and Pathophysiology of Neuroendocrine Neoplasms, Guido Rindi and Rajaventhan Srirajaskanthan
6.2. Neuroendocrine tumour markers, Whaljit Dhillo and Paul Bech
6.3. Carcinoid syndrome?, Rajaventhan Srirajaskanthan, Martyn E. Caplin, and Dominique Clement
6.4.1. Lung neuroendocrine tumours, Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor
6.4.2. Non-functioning pancreatic neuroendocrine tumours, Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor
6.5. Gastrinoma, Christos Toumpanakis and Martyn E. Caplin
6.6. Insulinoma and hypoglycaemia, Ashley Grossman and Ingrid YF Mak
6.7. Glucagonoma, Karim Meeran
6.8. Vasointestinal Polypeptide Secreting Tumours, Alia Munir
6.9. Somatostatinoma, John Wass
6.10. Imaging neuroendocrine tumours of the gastrointestinal tract/gastroenteropancreatic neuroendocrine tumours (GEP-NET), Prakash Manoharan
6.11. Multiple endocrine neoplasia type 1, Rajesh V. Thakker
6.12. Multiple endocrine neoplasia type 2a and 2b, Electron Kebebew, Douglas Wiseman, and Mustapha El Lakis
6.13. Familial syndromes and genetic causes of paraganglioma and phaeochromocytoma ?, Eamonn R. Maher and Ruth T. Casey
6.14. Carney s complex, Constantine A. Stratakis and Fabio Faucz
6.15. Molecular and Clinical Characteristics Of the McCune-Albright Syndrome, Michael A. Levine and Steven A. Lietman
6.16. Cowden syndrome, Charis Eng, Lamis Yehia, and Shreya Malhotra
7. Growth and development during childhood and adolescence
7.1. Growth and its Disorders
7.1.1. Recognising Normal and Disordered Growth, Gary Butler
7.1.2. Disorders of the GH-IGF Axis, Alexander A. L. Jorge, Fernanda A. Correa, and Renata C. Scalco
7.1.3. Short stature in children born small for gestational age, Anita Hokken-Koelega
7.1.4. Growth Disorders with no defined aetiology, Steve Chernausek and Minu George
7.1.5. Tall Stature, Lars Savendahl and Emelie Benji
7.2. Sex Development
7.2.1. Sex Determination and Differentiation, Olaf Hiort and Ralf Werner
7.2.2. Disorders of Sex Development (DSD) in the newborn, S. Faisal Ahmed and Salma R. Ali
7.2.3. Recognising Normal and Disordered Pubertal Development, Alan Rogol and John Fuqua
7.2.4. Pubertal Delay and Hypogonadism, Alan Rogol and John Fuqua
7.2.5. Precocious Puberty, Julianne Leger and Jean-Claude Carel
7.3. Transition In Endocrinology, Helena Gleeson and Rohana Wright
8. Female endocrinology and pregnancy
8.1. Normal female endocrinology and ovarian disorders
8.1.1. Neuroendocrinology of reproduction: the role of hypothalamus and pituitary, Chris McCartney and John Marshall
8.1.2. Ovarian and uterine development from fetal life to puberty, Terhi Piltonen and Juha Tapanainen
8.1.3. Menstrual cycle and ovulation, Gurkan Bozdag, Baris Ata, and Engin T?rkgeldi
8.2. Evaluation of the female patient with suspected reproductive endocrine disorders
8.2.1. Clinical evaluation of patient with suspected reproductive endocrine disorders, Channa Jayasena, Steve Franks, and Rachel Roberts
8.2.2. Laboratory evaluation, Daniel Dumesic and Zain Al-Safi
8.3. Reproductive endocrine disorders
8.3.1. Disorders of gonadotrophin secreton, Sarah L. Berga
8.3.2. Hyperprolactinaemia, Julian R. E. Davis and Agnieszka Swiecicka
8.3.3. Premenstrual syndrome, Deepthi Lavu, Radha Indusekhar, and Shaughn O'Brien
8.4. Polycystic ovary syndrome and other androgen excess disorders
8.4.1. Polycystic ovary syndrome: definitions, phenotypes, prevalence and genetics, Bulent Yildiz and Sezcan Mumusoglu
8.4.2. Polycystic ovary syndrome: reproductive aspects, R Jeffrey Chang
8.4.3. Polycystic ovary syndrome: metabolic aspects, David Ehrmann and Susan Sam
8.4.4. Polycystic ovary syndrome: Hirsutism, Duarte Pignatelli, Ricardo Azziz, and Bulent Yildiz
8.5. Female hypogonadism and menopause
8.5.1. Female hypogonadism: premature ovarian insufficiency, Ephia Yasmin and Gerard S. Conway
8.5.2. Female hypogonadism: Endocrinology of the menopause and hormone replacement therapy, Dimitrios G. Goulis, Stavroula A. Paschou, and Panagiotis Anagnostis
8.6. Female infertility
8.6.1. Female Infertility and assisted reproduction, Adam Balen and Susie Jacob
8.6.2. Female infertility: fertility preservation, Kutluk Oktay and Enes Taylan
8.7. Hormonal contraception
8.7.1. Hormonal contraception, Jennifer Chin Bliss Kaneshiro
8.8. Exogenous factors and female repoductive health
8.8.1. Exogenous factors and female reproductive health: common extragonadal endocrinopathies affecting reproduction, Alessandra Gambineri and Daniela Ibarra-Gasparini
8.8.2. Exogenous factors and female reproductive health: nutrition and reproduction, Siew Lim, Aya Mousa, Soulmaz Shorakae, and Lisa Moran
8.8.3. Exogenous factors and female reproductive health: envrionment and reproduction, Evy Diamanti-Kandarakis and Eleni A Kandaraki
9. Endocrinology of pregnancy
9.1. Endocrine disorders of Pregnancy
9.1.1. General considerations relating to thyroid disease in pregnancy, Peter Taylor, LDKE Premawardhana, and John Lazarus
9.1.2. Management of thyroid disorders before assisted and spontaneous pregnancy, Kris Poppe, Flora Veltri, and David Unuane
9.1.3. Thyroid disease during pregnancy, Tim Korevaar and Robin Peeters
9.1.4. Management of thyroid disorders after pregnancy, Nobuyuki Amino and Naoko Arata
9.1.5. Thyroid disorders in newborns, infants and children, A. S. Paul van Trotsenburg Nitash and Zwaveling-Soonawala
9.1.6. Pituitary tumours in pregnancy, Mark Molitch and Wenyu Huang
9.1.7. Other disorders of the pituitary and hypothalamus in pregnancy, Paul Carroll, Niki Karavitaki, and Kirstie Lithgow
9.1.8. Adrenal disease in pregnancy, David Torpy, Michael O'Reilly, and Sunita De Sousa
9.1.9. Endocrine bone disease in pregnancy, Jeremy Cox and Stephen Robinson
9.1.10. Imaging of endocrine disorders in pregnancy, Sandra Lowe
10. Male Reproductive Endocrinology
10.1. Normal male reproductive endocrinology
10.1.1. Endocrine and local regulation of testicular hormone and sperm production, Ilpo Huhtaniemi and Jorma Toppari
10.1.2. Sex steroid actions in the Male, Dirk Vanderschueren, Leen Antonio, Nari Kim, and Frank Claessens
10.2. Evaluation of the male patient with suspected hypogonadism and/or infertility
10.2.1. Clinical evaluation, Bradley Anawalt
10.2.2. Endocrine evaluation, Jean-Marc Kaufman
10.2.3. Diagnostic Semen analysis, Jackson Kirkman-Brown and Sarah J Conner
10.3. Male reproductive endocrine disorders
10.3.1. Klinefelter s syndrome, Claus H. Gravholt
10.3.2. Adult Hypogonadism: Aetiology
10.3.2.1. Etiology of Hypogonadism, Alvin Matsumoto and Radhika Narla
10.3.2.2. Types of Treatments, Giovanni Corona, Mario Maggi, and Giulia Rastrelli
10.3.2.3. Gonadotrophin induction of spermatogenesis, Michael Zitzmann
10.3.2.4. Male Hypogonadism: Benefits of Testosterone Treatment, Shehzad Basaria and Thiago Gagliano-Juca
10.3.2.5. Risks of T Treatment, Adrian Dobs and Swaytha Yalamanchi
10.3.3. Management of Idiopathic male infertility, Herman J. Tournaye and Biljana Popovic-Todorovic
10.3.4. Hypothalamo-pituitary-testicular axis fucntion in systemic diseases and effects of medications, Mathis Grossmann, B. Yeap, and Gary Wittert
10.3.5. Management of sexual dysfunction, Vincenzo Rochira, Antonio R. M. Granata, and Cesare Carani
10.3.6. Hormonal male contraception, Stephanie Page and Maritza Farrant
10.3.7. Gynaecomastia, Glenn Braunstein
10.4. Exogenous factors and male reproductive health
10.4.1. Environmental influences on male reproductive health, Jorma Toppari
10.4.2. Androgen Misuse and Abuse, David Handelsman
11. Management of the Transgender Patient
11.1. Introduction to Transgender and Gender Diverse People, Jon Arcelus and Walter Bouman
11.2. Endocrine Treatment of Transgender Youth, Daniel Klink
11.3. Hormone Therapy in transgender women, Vin Tangpricha and Craig Sineath
11.4. Hormone therapy in transgender men, Guy T'Sjoen and Justine Defreyne
11.5. Fertility Options for Transgender Persons?, Chlo? De Roo and Guy T'Sjoen
12. Endocrine Responses to Systemic Diseases or Substance Use
12.1. Endocrinology of systemic disease
12.1.1. The endocrine response to stress, David Henley, Thomas Upton, and Stafford L. Lightman
12.1.2. Endocrinology in the critically ill, Greet Van den Berghe and Lies Langouche
12.1.3. Hormones and the kidney, David Johnson, Melissa Nataatmadja, and Yeoungjee Cho
12.1.4. The endocrinology of liver disease, Jacob George and Mohammed Eslam
12.1.5. Endocrine abnormalities in HIV infection, Steven K. Grinspoon and Takara Stanley
12.1.6. The endocrinology of anorexia nervosa, Karen Miller
12.2. Endocrine Complications of Substance Misuse?
12.2.1. Endocrinology and alcohol, Marc Walter and Margit Proescholdt
12.2.2. Use and abuse of performance-enhancing hormones in sport, Peter Sonksen and Richard Holt
12.2.3. Effect of Opioids on Adrenal and Reproductive Endocrinology, Ashley Grossman, Eleni Armeni, and Bernard Khoo
13. Endocrinology of cancer
13.1. Endocrine Disorders Caused by Cancer or its Treatment
13.1.1. Metastatic Disease in Endocrine Organs, Thomas Papathomas and Vania Nose
13.1.2. Paraneoplastic endocrine syndromes, David W. Ray
13.1.3. Long-term endocrine sequelae of cancer therapy, Claire Higham and Rob Murray
13.1.4. Endocrine complications of biological cancer therapies, Carla Moran
13.2. Hormonal therapy for breast and prostatic cancers
13.2.1. The breast: lactation and breast cancer as an endocrine disease, Rob Clarke and Alice Greenhalgh
13.2.2. Endocrine treatment of breast cancer, Amna Sheri and Laura Morrison
13.2.3. Hormonal Therapy for Prostate Cancer: Molecular basis of efficacy and therapeutic bypass, Irina A. Vasilevskaya, Matthew J. Schiewer, and Karen E. Knudsen
14. Obesity, lipids, and metabolic disorders
14.1. Obesity
14.1.1. The Physiology of Bodyweight Regulation, Anthony Coll
14.1.2. Obesity as a Public Health Problem, Adrian Bauman
14.1.3. Medical Complications of Obesity?, Rachel Batterham and Friedrich Jassil
14.1.4. Dietary and Medical Management of Obesity, John Wilding and Jonathan Lim
14.1.5. Metabolic Surgery, Francesco Rubino, Vivian Anastasiou, Luca Ferraro, Dalal Qanaq, and Ghassan Chamseddine
14.1.6. Assessment of Obesity in Children, Sadaf Farooqi
14.1.7. Management of Obesity in Children and Young People, Russell Viner and Billy White
14.1.8. Planning obesity care pathways, Nick Finer
14.2. Lipoprotein metabolism and dyslipidaemia
14.2.1. Lipoprotein metabolism, Bo Angelin and Paolo Parini
14.2.2. Genetic forms of dyslipidaemia, Stefano Romeo, Bo Angelin, and Paolo Parini
14.3. Other metabolic disorders
14.3.1. Hyperinsulinaemic Hypoglycaemia, Khalid Hussain and Sonya Galcheva
14.3.2. Autoimmune Hypoglycaemia?, Phillip Gorden and Noemi Malandrino
14.3.3. Disorders of carbohydrate metabolism, Robin H. Lachmann
14.3.4. Haemochromatosis And Other Inherited Diseases Of Iron Metabolism, Yves Deugnier and Edouard Bardou-Jacquet
14.3.5. The porphyrias, Michael N. Badminton and Danja Schulenburg-Brand
15. Diabetes mellitus
15.1. Introduction to Diabetes Mellitus
15.1.1. Physiology of glucose homeostasis, Shanta Persaud and Peter Jones
15.1.2. Classification and diagnosis of diabetes mellitus, Stephen Colagiuri and Crystal Man Ying Lee
15.2. Aetiopathogenesis and Diagnosis of Type 1 Diabetes
15.2.1. Epidemiology and Public Health, Elizabeth J. Mayer-Davis and Daria Igudesman
15.2.2. Presentation and Natural History, Augustin Brooks
15.2.3. Pathogenesis, Richard Oram, Susan Wong, and Ayat Bashir
15.3. Aetiopathogenesis and Diagnosis of Type 2 Diabetes
15.3.1. Epidemiology and Public Health, Sarah Wild and Jackie Price
15.3.2. Presentation and Natural History, Roy Taylor
15.3.3. Pathogenesis, Mark Walker, Xuefei Yu, and Amalia Gastaldelli
15.4. Non Type 1, Non Type 2 Diabetes
15.4.1. Diagnosis of non type 1, non type 2 forms of diabetes, Katherine Owen
15.5. Principles of Management of Diabetes
15.5.1. Structured Education, Simon Heller and Jackie Elliott
15.5.2. Glucose Monitoring and Sensing, John Pickup and Nick Oliver
15.5.3. Insulins and insulin delivery devices, Pratik Choudhary and Peter Jacob
15.5.4. Non-insulin glucose lowering agents, Clifford Bailey and Melanie Davies
15.5.5. Hypoglycaemia in the treatment of diabetes mellitus, Stephanie Amiel
15.6. Evidence-based Management of Type 1 Diabetes
15.6.1. Strategies for management of type 1 diabetes, Peter Hammond and Fiona Campbell
15.6.2. Psychological and Behavioural Aspects of Type 1 Diabetes Management, Christel Hendrieckx and Jane Speight
15.6.3. Immunotherapy for type 1 diabetes, Colin Dayan and Danijela Tatovic
15.6.4. Transplantation (islet and solid organ), Peter Senior, Martin Drage, Anneliese Flatt, and Chris Callaghan
15.7. Evidence-based Prevention and Management of Type 2 Diabetes
15.7.1. Strategies for management of type 2 diabetes, Peter Winocour and Sagen Zac-Varghese
15.7.2. Psychological and Behavioural Aspects of Type 2 Diabetes Management, Jane Speight and Tim Skinner
15.7.3. Type 2 diabetes in different ethnic groups, Kamiesh Khunti and Nitin Narayan Gholap
15.7.4. Prevention of Type 2 Diabetes, Nicholas Wareham
15.8. Emerging Approaches to Restoring Euglycaemia in Diabetes
15.8.1. Regenerative medicine for diabetes, Michael White, Timothy J. Kieffer, and Cara Ellis
15.8.2. Closed loop, Roman Hovorka and Charlotte Boughton
15.9. Emergency and Hospital management of Diabetes
15.9.1. Hyperglycaemic Emergencies, Ketan Dhatariya
15.9.2. Management of the inpatient with diabetes mellitus, Gerry Rayman
15.9.3. Care of diabetes in ICU and peri-sugery, Greet Van Den Berghe and Jan Gunst
15.10. Specialised Management of Other forms of Diabetes
15.10.1. Monogenic forms of diabetes resulting from beta cell dysfunction, Andrew Hattersley, Kashyap Patel, and Rachel Besser
15.10.2. Lipodystrophies and severe insulin resistance, Anna Stears, David B. Savage, and Stephen O'Rahilly
15.10.3.1. Diabetes Secondary to Pancreatic Disease, Phil Weston
15.10.3.2. Diabetes Secondary to Endocrine Disorders, Jeremy Tomlinson
15.10.4. Diabetes in Pregnancy, Helen Murphy and Jennifer M Yamamoto
15.11. Psychiatry and Diabetes
15.11.1. Type 1 diabetes and Psychiatry, Khalida Ismail, Christopher Garrett, and Marietta Stadler
15.11.2. Type 2 diabetes and Psychiatry, Khalida Ismail, Hermione Price, Marilia Calcia, Calum Moulton, and Clare Whicher
15.12. Microvascular Complications of Diabetes
15.12.1. Pathogenesis of Microvascular Complications, Angela Shore
15.12.2. Retinopathy, Peter Scanlon
15.12.3. Diabetic Nephropathy, Luigi Gnudi and Sally Marshall
15.12.4. Diabetic Neuropathy, Solomon Tesfaye and Jing Wu
15.13. Macrovascular Disease in Diabetes
15.13.1. Mechanisms of macrovascular disease in diabetes, Mark Kearney, Peysh Patel, and Richard Cubbon
15.13.2. Macrovascular disease in type 2 diabetes, Naveed Sattar
15.13.3. Macrovascular disease in type 1 diabetes, John Petrie
15.13.4. Diabetic dyslipidaemia, Bruno Verg?s
15.13.5. Hypertension in diabetes mellitus, Bryan Williams
15.14. The Diabetic Foot
15.14.1. Modern management of diabetes-related foot disease, Frank Bowling and Andrew Boulton
15.15. Delivery of Diabetes Care
15.15.1. Diabetes service organisation, Jonathan Valabhji
15.15.2. Health Economics of Diabetes Care and Prevention, Philip Clarke and Tom Lung