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Written and edited by internationally recognized leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer.
Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment.
A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care.
The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.
David J. Kerr, Professor of Cancer Medicine, Nuffield Division of Clinical and Laboratory Sciences, University of Oxford, UK,Daniel G. Haller, Professor Emeritus, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA,Cornelius J. H. van de Velde, Professor of Surgery and Head,Department of Surgical Oncology, Leiden University Medical Center, The Netherlands,Michael Baumann, Professor and Chair, Department of Radiation Oncology; Director, University Cancer Center; and Coordinator, German Cancer Consortium (DKTK), Medical Faculty and University Hospital Carl Gustav Carus,Technical University of Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Germany; German Cancer Consortium (DKTK) partner site, Dresden, Germany; and German Cancer Center (DKFZ) Heidelberg, Germany,Nagahiro Saijo, Professor, Kinki University School of Medicine; Member of Executive AdvisoryBoard, West Japan Oncology Group; and Deputy Director of the National Cancer Center Hospital East,
David Kerr has made a sustained and internationally recognised contribution to cancer care and research in the field of medical oncology over the past three decades. He has published over 400 papers in high profile journals, authored over twenty books and has been awarded four prestigious, international research prizes, including the NHS's first Nye Bevan award for Innovation. His scientific standing has been recognised by election as Fellow of the Royal College of Physicians, Fellow of Academy of Medical Sciences, President of the European society of Medical Oncology (2009-2011) and Founding Fellow of the European Academy of Cancer Sciences.
Table of Contents
Section 1: Hallmarks of Cancer 1. The hallmarks of cancer, Douglas Hanahan and Robert A. Weinberg 2. Growth factors and uncontrolled proliferation, Shujuan Liu and Ahmed Ashour Ahmed 3. Cell signalling pathways, Stefan Knapp 4. Cell cycle control, Simon Carr and Nicholas La Thangue 5. Cancer cell death, Amanda S. Coutts, Sandra Maniam, and Nicholas La Thangue 6. Angiogenesis, Yull E. Arriaga and Arthur E. Frankel 7. Invasion and metastases, Andrew P. Mazar, Andrey Ugolkov, Jack Henkin, Richard Ahn, and Thomas V. O'Halloran 8. Genetic instability, Sir Walter Bodmer and Jenny Wilding 9. DNA repair after oncological therapy, E. Dikomey, K. Borgmann, M. Kriegs, W. Mansour, C. Petersen, and T. Rieckmann 10. Biology of cancer stem cells, Andreas Trumpp 11. Biomarker identification and clinical validation, Richard D Kennedy, Manuel Salto-Tellez, D. Paul Harkin, and Patrick G Johnston 12. Cancer, immunity, and inflammation, Campbell SD Roxburgh and Donald C McMillan 13. Cancer and metabolism, Cameron Snell, Kevin C Gatter, Adrian L Harris, Francesco Pezzella Section 2: Etiology and Epidemiology of Cancer 14. Smoking and cancer, Jonathan Samet 15. Viruses, Chris Boshoff 16. Chemical carcinogens, Paula A. Oliveira 17. Radiation, Klaus Trott 18. Body fatness, physical activity, diet, and other lifestyle factors, Ellen Kampman and Franzel van Duijnhoven Section 3: Principles of Oncology 19. Practice points for surgical oncology, PG Boelens, CBM van den Broek, and CJH van de Velde 20. Practice points for radiation oncology, Annekatrin Singer, Stephanie E. Combs, Jurgen Debus, and Michael Baumann 21. Principles of chemotherapy, David Kerr, Daniel Haller, and Jaap Verweij 22. Delivery of multidisciplinary cancer care, David N Church, Rachel S Midgley, and David J Kerr 23. Principles of clinical pharmacology: Introduction to pharmacokinetics and pharmacodynamics, Michael Ong and Udai Banerji 24. Design and analysis of clinical trials, Dan Sargeant and Qian Shi 25. Medical ethics in oncology, Eric A. Singer 26. Health economic assessment of cancer therapy, Jeffrey Peppercorn Section 4: Population Health 27. Cancer control: The role of national plans, Masoud Samiei 28. Cancer prevention: Vaccination, Sarah Goltz and Julian Lob-Levyt 29. Cancer prevention: Chemoprevention, Hans-Joerg Senn, Nadir Arber, and Dirk Schrijvers 30. Population cancer screening, Andrew Evans, Simon Herrington, and Robert Steele 31. Familial cancer syndromes and genetic counselling, Henry T. Lynch, Carrie L. Snyder, and Jane F. Lynch (deceased) Section 5: Support for the cancer patient 32. Supportive palliative care, David Hui and Eduardo Bruera 33. Quality of life, Neil Aaronson and Peter Fayers 34. Cancer survivorship and rehabilitation, Rachel L. Yung and Ann H. Partridge Section 6: Disease 35. Cancer of the head and neck, Christine Chung, Andreas Dietz, Vincent Gregoire, Marco Guzzo, Marc Hamoir, Rene Leemans, Jean-Louis Lefebvre, Lisa Licitra, Adel El-Naggar, Brian O?Sullivan, Bing Tan, Vincent Vandecaveye, Vincent Vander Poorten, Jan Vermorken, and Michelle Williams 36. Oesophageal cancer, Eric Van Cutsem, Christophe M. Deroose, Piet Dirix, Karin Haustermans, Tony Lerut, Philippe Nafteux, Hans Prenen, and Xavier Sagaert 37. Gastric cancer, Hideaki Bando, Takahiro Kinoshita, Yasutoshi Kuboki, Atsushi Ohtsu, and Kohei Shitara 38. Rectal cancer, Regina Beets-Tan, Bengt Glimelius, and Lars Pahlman 39. Colon cancer, John Zalcberg, Stephen Fox, Alexander Heriot, Jon Knowles, Sam Ngan, Michael Michael, Kathryn Field, and Iris Nagtegaal 40. Pancreatic cancer, J. Weitz, M.W. Buchler, Paul D Sykes, John P Neoptolemos, Eithne Costello, Christopher M Halloran, Frank Bergmann, Peter Schirmacher, Ulrich Bork, Stefan Fritz, Jens Werner, Thomas Brunner, Elizabeth Smyth, David Cunningham, Brian R. Untch, and Peter J. Allen 41. Hepatobiliary cancer, Graeme J Poston, Nicholas Stern, Jonathan Evans, Priya Healey, Daniel Palmer, and Mohandas K. Mallath 42. Peritoneal mesothelioma, H. Richard Alexander, Jr., Dario Baratti, Terence C. Chua, Marcello Deraco, Raffit Hassan, Marzia Pennati, Federica Perrone, Paul H. Sugarbaker, Anish Thomas, Keli Turner, Tristan D. Yan and Nadia Zaffaroni 43. Cancer of the breast, Martine Piccart, Toral Gathani, Dimitrios Zardavas, Hatem A. Azim Jr., Christos Sotiriou, Giuseppe Viale, Emiel J T Rutgers, Mechthild Krause, Monica Arnedos, Suzette Delaloge, Fabrice Andre, and Felipe Ades 44. Gynaecological cancers, Richard Potter, Shujuan Liu, Bolin Liu, Sebastien Gouy, Sigurd Lax, Eric Leblanc, Philippe Morice, Fabrice Narducci, Alexander Reinthaller, Maximilian P Schmid, Catherine Uzan, and Pauline Wimberger 45. Genitourinary cancer, John Fitzpatrick, Asif Muneer , Jean de la Rosette, and Thomas Powles 46. Lung cancer, Rafal Dziadziuszko, Michael Baumann, Tetsuya Mitsudomi, Keith M. Kerr, Solange Peters, and Stefan Zimmermann 47. Neoplasms of the thymus, Rebecca Butof, Axel Denz, Gustavo Baretton, Jan Stohlmacher-Williams, and Michael Baumann 48. Pleural mesothelioma, Andrea S. Wolf, Assunta De Rienzo, Raphael Bueno, Lucian R. Chirieac, Joseph Corson, Elizabeth H. Baldini, David Jackman, Ritu Gill, Walter Weder, Isabelle Opitz, Ann S. Adams, and David J. Sugarbaker 49. Skin cancer: melanoma, John F Thompson, Richard A Scolyer, and Richard F Kefford 50. Skin cancer: non-melonoma, Diona L. Damian, Richard A. Scolyer, Graham Stevens, Alexander Menzies, and John F. Thompson 51. Acute leukemia, Adele K. Fielding, Charles G. Mullighan, Dieter Hoelzer, Eytan M. Stein, Ghada Zakout, Martin S. Tallman, Ross Levine, Yishai Ofran, Jacob M. Rowe, and Ross L. Levine 52. Chronic leukemias, Hemant Malhotra, Lalit Kumar, Pankaj Malhotra, Devendra Hiwase, and Ravi Bhatia 53. Myeloma, Charlotte Pawlyn, Faith Davies, and Gareth Morgan 54. Lymphomas, Frank Kroschinsky, Friedrich Stolzel, Stefano A. Pileri, Bjoern Chapuy, Rainer Ordemann, Christian Gisselbrecht, Tim Illidge, David C. Hodgson, Mary K. Gospodarowicz, Christina Schutze, and Gerald Wulf 55. Sarcomas of the soft tissue, Alessandro Gronchi, Angelo P. Dei Tos, and Paolo G. Casali 56. Cancer of the central nervous system, Puneet Plaha, Allyson Parry, Pieter Pretorius, Michael Brada, Olaf Ansorge, and Claire Blessing 57. Cancer of the eye and orbit, Daniel G. Ezra, Geoffrey E. Rose, Jacob Pe'er, Sarah Coupland, S. Seregard, G.P.M. Luyten, and Annette C. Moll 58. Endocrine cancers, David Kerr, Andrew Weaver, Anthony P. Weetman, Oliver Gimm, Ashley Grossman, Petra Sulentic, Bertram Wiedenmann, Ulrich-Frank Pape, John Wass, Angela Rogers, and W de Herder 59. Cancer of unknown primary site, Nicholas Pavlidis and George Pentheroudakis Index