Oxidative Stress Diagnostics, Prevention, and Therapy

by Andreescu, Silvana; Hepel, Maria

• ISBN13: 9780841226838
• ISBN10: 0841226830
• Format: Hardcover
• Copyright: 2012-04-17
• Publisher: American Chemical Society

Summary

Oxidative stress is the state of a diminished capacity of a biological system to counteract an overproduction or invasion of reactive oxygen species and other radicals. This book presents recent advancements in the understanding of oxidative stress, the mechanisms of damage to cells and biomolecules, and pathological implications in disorders including Alzheimer's disease, Parkinson's Disease, cardiovascular disease, cell damage in HIV-AIDS, stroke, autism and premature aging. Thebook is a comprehensive source of information describing new directions in diagnostics of oxidative stress, including novel detection methods of oxidative-stress biomarkers, prevention by antioxidants, and therapy using novel free radical scavenging agents and natural defense systems.

Table of Contents

Preface	p. ix
The Role of Antioxidants in Human Health	p. 1
Pathophysiological Implications of Altered Redox Balance in HIV/AIDS Infection: Diagnosis and Counteract Interventions	p. 39
Thermodynamics of Free Radical Reactions and the Redox Environment of a Cell	p. 71
Oxidative Stress in the Metabolism of Estrogens Leading to Cancer Initiation: Prevention by Specific Antioxidants	p. 83
Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms in E. colt and Human Cells	p. 99
DNA-Protective Mechanisms of Glutathione Intervention in Catechol-Mediated Oxidative DNA Damage in the Presence of Copper(II) Ions	p. 177
Antioxidant Effectiveness in Preventing Paraquat-Mediated Oxidative DNA Damage in the Presence of H2O2	p. 211
Artificial Nanoparticle Antioxidants	p. 235
Cerium Oxide Nanoparticles for the Treatment of Neurological Oxidative Stress Diseases	p. 255
Detection of Superoxide and Hydrogen Peroxide from Living Cells Using Electrochemical Sensors	p. 289
Peroxynitrite and Nitroxidative Stress: Detection Probes and Micro-Sensors. A Case of a Nanostructured Catalytic Film	p. 311
Blue Native PAGE and Mass Spectrometry as an Approach for the Investigation of Stable and Transient Protein-Protein Interactions	p. 341
Mass Spectrometry for Proteomics-Based Investigation of Oxidative Stress and Heat Shock Proteins	p. 369
Editors' Biographies	p. 413
Indexes
Author Index	p. 417
Subject Index	p. 419
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