Pathogenesis of Bacterial Infections in Animals, 4th Edition

by Editor: Carlton L. Gyles (University of Guelph); Editor: John F. Prescott (University of Guelph); Editor: Glenn Songer (University of Arizona ); Editor: Charles O. Thoen (Chair and Professor of the Dept of Veterinary Microbiology and Preventive M

• ISBN13: 9780470958216
• ISBN10: 0470958219
• Format: eBook
• Copyright: 2010-04-01
• Publisher: Wiley-Blackwell

Summary

Pathogenesis of Bacterial Infections in Animals, Fourth Edition captures the rapid developments in understanding the mechanisms of virulence of the major bacterial pathogens of animals. Now including a color plate section, the book presents an overview of pathogenesis, including relevant events that occur in the herd or flock and its environment, and activities that take place at the cellular and molecular levels. With contributions from 64 experts in the field, this book serves as a great reference for graduate students in veterinary medicine and animal science, microbiologists, virologists and pathologists.

Table of Contents

Preface

Contributors

Themes in Bacterial Pathogenic Mechanisms

Introduction

Basic Steps in Pathogenesis Continue to Provide a Sound Foundation

Concepts of Virulence are Being Refined

Host-Bacteria Communication is Critical

Pathogenesis in the Post-Genomic Era

Evolution of Pathogens-The Path Traveled May Provide Insights into the Road Ahead

Subversion of the Immune Response by Bacterial Pathogens

Introduction

Subversion of Innate Immune Responses

Subversion of Adaptive Immunity

Conclusion

Evolution of Bacterial Virulence

What are Pathogens and How do They Emerge?

Bacterial Fitness and Virulence

Sources of Genetic Diversity, Population Structure, and Genome Plasticity

Pathogenicity Islands

Bacteriophages and Their Role in Pathogen Evolution and Virulence

Illustrations of Virulence Evolution

Conclusion

Streptococcus

Introduction

Streptococcus agalactiae

Streptococcus dysgalactiae

Streptococcus uberis

Streptococcus equi

Streptococcus zooepidemicus

Streptococcus canis

Streptococcus porcinus

Streptococcus suis

Streptococcus pneumoniae

Gaps in Knowledge and Anticipated Developments

Staphylococcus

Introduction

Characteristics of the Organism

Pathogenic Staphylococcus Species

Sources of the Bacterium

Bacterial Virulence Factors

Pathogenesis

Types of Disease and Pathologic Changes

Interactions between the Bacterium and Host Defenses

Immunity and Its Impact on Pathogenesis

Conclusions: New Developments

Bacillus anthracis

Introduction

Etiology, Ecology, and Epidemiology

Symptomatology and Diagnosis

Bacteriology

Pathogenesis

Immunology

Control

Future Directions

Mycobacterium

Introduction

Characteristics and Sources of the Organisms

Bacterial Virulence Factors

Pathogenesis

Immunity

Gaps in Knowledge and Anticipated Developments

Corynebacterium and Arcanobacterium

Corynebacterium

Corynebacterium pseudotuberculosis

Other Corynebacteria

Arcanobacterium

Arcanobacterium pyogenes

Future Directions

Rhodococcus

Introduction

Characteristics and Sources of the Organism

Bacterial Virulence Factors

Pathogenesis

Gaps in Knowledge and Anticipated Developments

Listeria

Introduction

Characteristics

Sources of Infection

Virulence Factors

Pathogenesis

Host-Pathogen Interactions in Listeriosis

Prevention and Treatment

Conclusion

Neurotoxigenic Clostridia

Introduction

Clostridium tetani and Clostridium botulinum

Toxins

Tetanus

Botulism

Control and Prevention

BoNT as Therapeutics

Conclusions

Histotoxic Clostridia

Introduction

Virulence Factors and Pathogenesis

Clostridium perfringens

Clostridium septicum

Clostridium chauvoei

Clostridium novyi

Clostridium sordellii

Conclusion

Enteric Clostridia

Introduction

Clostridium perfringens

Clostridium difficile

Clostridium septicum

Clostridium spiroforme

Clostridium piliforme

Gaps in Knowledge and Anticipated Developments

Salmonella

Introduction

Salmonella Infections of Cattle

Salmonella Infections of Sheep

Salmonella Infections of Pigs

Infections of Domestic Fowl and Other Avian Species

Colonization of the Intestine

Salmonella Invasion and Enteropathogenesis

Systemic Disease

Genome Structure with Reference to Virulence

Immunity to Infection and Its Manipulation by Salmonella

Conclusion-Problems and Opportunities

Color Plate Section

Escherichia coli

Introduction

Types of Escherichia coli Implicated in Disease

ETEC

Pathogenesis of ETEC

STEC

EPEC

ExPEC

Immunity

Conclusions

Yersinia

Introduction

Classifi cation of Yersinia Species

Sources of Yersinia Species

Virulence Factors

Pathogenesis

Vaccines

Future Directions

Pasteurella

Introduction

Characteristics and Sources of the Organisms

Diseases Caused by Pasteurella multocida

Pasteurella multocida : Bacterial Virulence Factors

Pathogenesis

Immunity in Pasteurella multocida Infections

Gaps in Knowledge and Anticipated Developments

Acknowledgment

Mannheimia

Introduction

Characteristics and Sources of Mannheimia

Bacterial Virulence Factors

Pathogenesis and Disease

Gaps in Knowledge and Anticipated Developments

Acknowledgments

Actinobacillus

Actinobacillus pleuropneumoniae

Actinobacillus lignieresii

Actinobacillus equuli

Actinobacillus suis

Future Prospects

Haemophilus

Introduction

Characteristics

Habitat and Transmission

Histophilus somni

Haemophilus parasuis

Avibacterium paragallinarum

Conclusions

Bordetella

Introduction

Characteristics of the Genus

Sources of the Bacteria

Virulence Factors

Pathogenesis

Conclusion

Brucella

Introduction

Characteristics and Sources of the Organisms

Bacterial Virulence Factors

Pathogenesis

Disease Control and Epidemiology

Gaps in Knowledge and Anticipated Developments

Pseudomonas

Introduction

Overview of Pathogenesis

Virulence Factors of Pseudomonas aeruginosa

Antibiotic Resistance

Impact of Whole Genome Sequences

Vaccines

Conclusions and Future Prospects

Moraxella

Introduction

Infectious Bovine Keratoconjunctivitis

Pathogenesis of Moraxella bovis

Conclusions

Campylobacter and Helicobacter

Campylobacter

Helicobacter

Gastric Helicobacters

Enterohepatic Helicobacters

Pathogenesis and Virulence Factors

Conclusions

Lawsonia intracellularis

Characteristics of Lawsonia intracellularis

Sources of Lawsonia intracellularis

Virulence Factors

Pathogenesis

Conclusion

Gram-negative Anaerobes

Introduction

General Bacterial Virulence Factors

Fusobacterium

Bacteroides

Prevotella and Porphyromonas

Dichelobacter

Treponema

Brachyspira

Gaps in Knowledge and Anticipated Developments

Leptospira

Leptospira -The Basics

Leptospirosis-The Disease

Genomics, Proteomics, and Molecular Biology

Pathogenesis of Leptospirosis

Mechanisms of Immunity in Leptospirosis

Diagnosis of Leptospirosis and The Typing of Isolates

Gaps in Knowledge and Anticipated Developments

Acknowledgments

Mycoplasma

Introduction

Characteristics of the Organism

Sources of the Bacterium

Bacterial Virulence Factors

Pathogenesis

Interactions

Protective Immunity

Conclusions

Chlamydia

Introduction

Classifi cation

Host-Parasite Relationship: Clinical Disease and Pathogenesis

Life Cycle

Aberrant Development Cycle

Host Response

Prevention and Control

Future Directions

Rickettsiales

Introduction

Family Anaplasmataceae

Family Rickettsiaceae

Index

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