Pathophysiology and Clinical Applications of Nitric Oxide

by Rubanyi; Gabor M.

• ISBN13: 9789057024153
• ISBN10: 9057024152
• Format: Hardcover
• Copyright: 1999-06-23
• Publisher: CRC Press

Summary

Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Table of Contents

Preface	xi
Contributors	xiii
The Beginnings of Research on Nitric Oxide in Biology: A Historical Perspective	1	(16)
R.F. Furchgott
I. Generation and Biological Actions of Nitric Oxide
Structural Variations on a Theme of Nitric Oxide Production by Three Isoforms of Nitric Oxide Synthase	17	(22)
B.S. Masters
P. Martasek
L.J. Roman
Nitric Oxide Synthase Gene Regulation	39	(12)
K.K. Wu
Localization and Subcellular Targeting of Nitric Oxide Synthases	51	(8)
G. Garcia-Cardena
W.C. Sessa
Molecular Mechanisms of Peroxynitrite Reactivity	59	(10)
A.J. Gow
H. Ischiropoulos
Nitric Oxide, Peroxynitrite and Poly (ADP-Ribose) Synthetase: Biochemistry and Pathophysiological Implications	69	(30)
C. Szabo
Nitric Oxide and Gene Transcription	99	(22)
J.K. Liao
P. Libby
Nitric Oxide and the Regulation of Vasoactive Genes	121	(34)
D.V. Faller
Cyclooxygenase: An Important Transduction System for the Multifaceted Roles of Nitric Oxide	155	(16)
D. Salvemini
Regulation of Nitric Oxide Synthase Expression and Activity by Hemodynamic Forces	171	(24)
B.E. Sumpio
B.O. Oluwole
X. Wang
M.A. Awolesi
Nitric Oxide Synthase Regulation by 17β-Estradiol	195	(14)
K. Kauser
G.M. Rubanyi
Mice Deficient in eNOS and nNOS Isoforms	209	(20)
P.L. Huang
II. Nitric Oxide and Pathophysiology of Diseases
Nitric Oxide and Its Role in Hemostasis	229	(22)
E.M. Battinelli
M.R. Trolliet
J. Loscalzo
Hypertension	251	(16)
E. Nava
T.F. Luscher
Pulmonary Hypertension	267	(16)
J. Dupuis
D. Langleben
D.J. Stewart
Atherosclerosis: Role of NO	283	(18)
J.P. Cooke
P.S. Tsao
Nitric Oxide in Myocardial and Splanchnic Ischaemia/Reperfusion	301	(22)
A.M. Lefer
R. Scalia
Nitric Oxide and Circulatory Shock	323	(12)
C. Thiemermann
Kidney Diseases	335	(14)
P. Gross
H. Dorniok
D. Reimann
M. Plug
The Role of Nitric Oxide in Preterm Labour and Pre-eclampsia	349	(26)
R.E. Garfield
I. Buhimschi
G.R. Saade
K. Chwalisz
Multiple Sclerosis	375	(22)
J.E. Merrill
Regulation of Nitric Oxide and Inflammatory Mediators in Human Osteoarthritis-Affected Cartilage: Implication for Pharmacological Intervention	397	(16)
A.R. Amin
M.G. Attur
S.B. Abramson
The Role of Nitric Oxide in Rheumatoid Arthritis	413	(12)
M. Stefanovic-Racic
C.H. Evans
Gastrointestinal Function in Shock	425	(30)
A.L. Salzman
III. Therapeutic Applications
Nitric Oxide Donors	455	(16)
J.A. Hrabie
L.K. Keefer
Nitric Oxide Inhalation	471	(34)
A.M. Atz
D.L. Wessel
Nitric Oxide Synthase Inhibitors	505	(18)
J.F. Parkinson
J.J. Devlin
G.B. Phillips
The Pharmacology of Peroxynitrite-Dependent Neurotoxicity Blockade	523	(16)
J.S. Althaus
G.J. Fici
P.F. Von Voigtlander
Hemoglobin: Its Role as a Nitric Oxide Scavenger	539	(16)
S.R. Fischer
D. L. Traber
Therapeutic Implications of Recombinant Endothelial Nitric Oxide Synthase Gene Expression in Cerebral and Peripheral Arteries	555	(14)
A.F.Y. Chen
T. O'Brien
Z.S. Katusic
Gene Therapy Approaches with iNOS	569
E. Tzeng
T.R. Billiar
Index	I/1