Pediatric Psychopharmacology : Principles and Practice

by Andrés Martin; Lawrence Scahill; Dennis S. Charney; James F. Leckman

• ISBN13: 9780195141733
• ISBN10: 0195141733
• Format: Hardcover
• Copyright: 2002-10-17
• Publisher: Oxford University Press, USA

Summary

Pediatric Psychopharmacology: Principles and Practice is an authoritative and comprehensive text on the use of medication in the treatment of children and adolescents with serious neuropsychiatric disorders. This benchmark volume consists of 56 chapters written by internationally recognizedleaders, and is divided into four interrelated sections. The first, Biological Bases of Pediatric Psychopharmacology, reviews key principles of neurobiology and the major psychiatric illnesses of childhood from a perspective rooted in developmental psychopathology. The second, SomaticInterventions, presents the major classes of psychiatric drugs, as well as complementary and alternative somatic interventions, such as electroconvulsive therapy (ECT), transcranial magnetic stimulation (rTMS), and naturopathic approaches. The third and longest section, Assessment andTreatment,starts with clinical assessment, diagnostic evaluation, and comprehensive treatment planning, and goes on to cover the evidence-based analysis of drug treatments for the major disorders. Special populations (such as children with comorbid mental retardation, substance abuse or medicalillness) are specifically discussed, and the coordination of their treatment with non-somatic therapies is explicitly addressed. The final section, Epidemiologic, Research, and Methodological Considerations, deals with broad population-relevant topics such as regulation and policy,pharmacoepidemiology, and the critical importance of sound ethical principles for clinical investigation. The book concludes with an appendix on generic and commercial drug name equivalencies, preparations, and available dosages. This timely text is intended for child and adolescent psychiatrists, general and developmental pediatricians, family practitioners, general psychiatrists, and other mental health professionals who work with children and adolescents.

Table of Contents

Contributors	p. xv
Biological Bases of Pediatric Psychopharmacology
Developmental Principles of Neurobiology and Psychopharmacology
Overview of Brain Development	p. 3
Synaptic Function and Biochemical Neuroanatomy	p. 20
Mechanisms of Signal Transduction and Adaptation to Psychotropic Drug Action	p. 33
Pharmacokinetics I: Developmental Principles	p. 44
Pharmacokinetics II: Cytochrome P450-Mediated Drug Interactions	p. 54
Genetic Principles
Molecular Genetics	p. 69
Pharmacogenetics	p. 84
Developmental Psychopathology
Neurobiology of Attention Regulation and its Disorders	p. 99
Neurobiology of Early-Life Stress and its Disorders	p. 110
Neurobiology of Early-Onset Mood Disorders	p. 124
Neurobiology of Early-Onset Anxiety Disorders	p. 138
Neurobiology of Obsessive-Compulsive Disorder	p. 150
Neurobiology of Tic Disorders, Including Tourette's Syndrome	p. 164
Neurobiology of Immune-Mediated Neuropsychiatric Disorders	p. 175
Neurobiology of Childhood Schizophrenia and Related Disorders	p. 184
Neurobiology of Affiliation: Implications for Autism Spectrum Disorders	p. 195
Neurobiology of Aggression	p. 210
Neurobiology of Eating Disorders	p. 224
Neurobiology of Substance Abuse and Dependence Disorders	p. 238
Somatic Interventions
Psychotropic Agents
Stimulants	p. 255
Adrenergic Agonists: Clonidine and Guanfacine	p. 264
Antidepressants I: Selective Serotonin Reuptake Inhibitors	p. 274
Antidepressants II: Tricyclic Agents	p. 284
Antidepressants III: Other Agents	p. 295
Mood Stabilizers: Lithium and Anticonvulsants	p. 309
Antipsychotic Agents: Traditional and Atypical	p. 328
Anxiolytics: Benzodiazepines, Buspirone, and Others	p. 341
Miscellaneous Compounds: Beta-Blockers and Opiate Antagonists	p. 353
Other Somatic Interventions
Complementary and Alternative Medicine in Pediatric Psychopharmacology	p. 365
Electroconvulsive Therapy and Transcranial Magnetic Stimulation	p. 377
Assessment and Treatment
General Principles
Clinical Assessment of Children and Adolescents Treated Pharmacologically	p. 391
Clinical Instruments and Scales in Pediatric Psychopharmacology	p. 404
Thinking About Prescribing: The Psychology of Psychopharmacology	p. 417
Combining Pharmacotherapy and Psychotherapy: An Evidence-Based Approach	p. 426
Specific Disorders and Syndromes
Attention-Deficit Hyperactivity Disorder	p. 447
Depressive Disorders	p. 466
Bipolar Disorder	p. 484
Anxiety Disorders	p. 497
Obsessive-Compulsive Disorder	p. 511
Tourette's Syndrome and Other Tic Disorders	p. 526
Early-Onset Schizophrenia	p. 543
Autistic and Other Pervasive Developmental Disorders	p. 563
Post-traumatic Stress Disorder	p. 580
Eating Disorders	p. 592
Special Clinical Populations
Substance-Abusing Youths	p. 605
Individuals with Mental Retardation	p. 617
The Medically Ill Child or Adolescent	p. 631
Psychopharmacology During Pregnancy: Infant Considerations	p. 642
Psychopharmacological Treatment of Preschoolers	p. 654
Other Areas of Clinical Concern
Agitation and Aggression	p. 671
Elimination Disorders: Enuresis and Encopresis	p. 686
Epidemiological, Research, and Methodological Considerations
Pediatric Psychopharmacoepidemiology: Who Is Prescribing? And For Whom, How, and Why?	p. 701
Clinical Trials Methodology and Design Issues	p. 712
Regulatory Issues	p. 725
Ethical Issues in Research	p. 737
International Perspectives	p. 746
Pediatric Psychopharmacology at a Glance	p. 757
Index	p. 765
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