Peptidomics Methods and Applications

by Soloviev, Mikhail; André; n, Per; Shaw, Chris

• ISBN13: 9780471677819
• ISBN10: 0471677817
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-12-14
• Publisher: Wiley-Interscience

Summary

The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Author Biography

Mikhail Soloviev is a Senior Lecturer in Biological Chemistry at theRoyal Holloway University of London and serves as the Editor-in-Chiefof the Journal of Nanobiotechnology. CHRIS SHAW is a Professor in DrugDiscovery in the School of Pharmacy at Queen's University in Belfast.PER ANDRéN is an Adjunct Professor in the Department of Pharmaceutical Biosciences at Uppsala University in Sweden.

Table of Contents

Studies of Naturally Occurring Peptides

Analysis of the peptidomes of amphibian skin granular gland secretions - an integrated functional genomic strategy

A short history of insect (neuro)peptidomics - A personal story of the birth and youth of an excellent model for studying peptidome biology

Peptidomics of short linear cytolytic peptides from spider venom

Molecular cloning approaches to peptidomics: the identification of novel cDNAs encoding neurotoxin-like peptide pools

Wheat antimicrobial peptides

Immunopeptidomics: Applications to dissect immune responses through proteomic-based approaches

Strategies for reliable and improved identification of peptides

Peptidomics Methods and New Developments

Peptidomics approach to proteomics

The importance of sample handling in neuropeptidomics

Affinity peptidomics and protein microarrays: application to forensics and biometrics

Selective depletion and enrichment methods for the analysis of protein and peptide pools

Detection of target peptides in foods and feeds by mass spectrometry

Quantification of Polypeptides by Mass Spectrometry

Peptidomics Approach to Biomarker Discovery

Biomarker discovery

Can peptidomics provide a useful approach for the identification of biomarkers of toxicological exposure or effect

Peptidomics in Neuroendocrine research: a Caenorhabditis elegans and Mus musculus study

Conclusion

Peptidomics and Biology: two scientific disciplines driving each other

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