Pharmacogenetics of Breast Cancer: Towards the Individualization of Therapy

by Leyland-Jones; Brian

• ISBN13: 9781420052930
• ISBN10: 1420052934
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-05-19
• Publisher: CRC Press

Summary

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become routine for the clinical practice.

Table of Contents

Preface	p. iii
Acknowledgments	p. v
Contributors	p. xi
Pharmacogenetics of Breast Cancer: Toward the Individualization of Therapy	p. 1
Pharmacology, Pharmacogenetics, and Pharmacoepidemiology: Three P's of Individualized Therapy	p. 11
Role of Genetic Variability in Breast Cancer Treatment Outcomes	p. 25
The Role of Epigenetics in Breast Cancer: Implications for Diagnosis, Prognosis, and Treatment	p. 45
Comparative Genomic Hybridization and Copy Number Abnormalities in Breast Cancer	p. 61
Gene Expression Profiling as an Emerging Diagnostic Tool to Personalize Chemotherapy Selection for Early Stage Breast Cancer	p. 77
Gene Expression-Based Predictors of Prognosis and Response to Chemotherapy in Breast Cancer	p. 97
Utilization of Genomic Signatures for Personalized Treatment of Breast Cancer	p. 107
Personalized Medicine by the Use of Microarray Gene Expression Profiling	p. 123
Predictive Markers for Targeted Breast Cancer Treatment	p. 135
Circulating Tumor Cells in Individualizing Breast Cancer Therapy	p. 151
Individualization of Endocrine Therapy in Breast Cancer	p. 167
TAILORx: Rationale for the Study Design	p. 185
Taking Prognostic Signatures to the Clinic	p. 197
Tissue is the Issue	p. 213
Acquisition and Preservation of Tissue for Microarray Analysis	p. 231
Tapping into the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Gold Mine for Individualization of Breast Cancer Treatment	p. 243
Breast Cancer Stem Cells and Their Niche: Lethal Seeds in Lethal Soil	p. 259
Molecular Imaging in Individualized Cancer Management	p. 291
Cancer Nanotechnology for Molecular Profiling and Individualized Therapy	p. 309
Index	p. 323
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