Pharmacogenetics and Individualized Therapy

by Maitland-van der Zee, Anke-Hilse; Daly, Ann K.

• ISBN13: 9780470433546
• ISBN10: 047043354X
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-05-08
• Publisher: Wiley

Summary

Pharmacogenetics focuses on genetic determinants of drug response at the level of single genes. Pharmacogenetics and Individualized Therapy presents a thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. With an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics. With contributions from academic and industrial leaders, the book sheds light on specific therapeutic areas and clinical aspects.

Author Biography

Anke-Hilse Maitland-van der Zee, PhD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands. Ann K. Daly, PhD, is Professor of Pharmacogenetics at Newcastle University, UK.

Table of Contents

Preface	p. vii
Contributors	p. ix
Pharmacogenetics: A Historical Perspective	p. 1
Pharmacogenetics: Relationship to Pharmacokinetics and Pharmacodynamics
Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes	p. 15
Pharmacogenetics of Phase H Drug Metabolizing Enzymes	p. 81
Pharmacogenetics of Drug Transporters	p. 101
Pharmacogenetics of Drug Targets	p. 149
Pharmacogenetics: Therapeutic Areas
Cardiovascular Pharmacogenetics	p. 185
Pharmacogenetics in Psychiatry	p. 215
Pharmacogenetics in Cancer	p. 251
Pharmacogenetics of Asthma and COPD	p. 271
Pharmacogenetics of Adverse Drug Reactions	p. 295
Pharmacogenomics of Inflammatory Bowel Diseases	p. 323
Pharmacogenetics of Pain Medication	p. 353
Pharmacogenetics: Implementation in Clinical Practice
Ethical and Social Issues in Pharmacogenomics Testing	p. 377
Developments in Pharmacogenetic Research
High-Throughput Genotyping Technologies for Pharmacogenetics	p. 403
Developments in Analyses in Pharmacogenetic Datasets	p. 415
Pharmacogenetics: Industry and Regulatory Affairs
Applications of Pharmacogenetics in Pharmaceutical Research and Development	p. 439
Role of Pharmacogenetics in Registration Processes	p. 461
Conclusions
Pharmacogenetics: Possibilities and Pitfalls	p. 479
Index	p. 485
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