Pharmacology

by Rosenfeld, Gary C.

• ISBN13: 9780683180503
• ISBN10: 0683180509
• Format: Trade Paper
• Copyright: 1997-10-01
• Publisher: Williams & Wilkins

Summary

This concise review of medical pharmacology is designed for medical students, dental students, and others in the health care professions. It is intended primarily to help students prepare for licensing examinations such as the USMLE Step 1 or similar examinations. Each chapter presents specific drugs and discusses their general properties, mechanism of action, pharmacologic effects, therapeutic uses, and adverse effects. Drug lists and two-color tables and figures summarize essential drug information in all chapters. Clinically oriented USMLE-style review questions and answers with explanations follow each chapter. A comprehensive examination consisting of USMLE-style questions appears at the end of the book.

Table of Contents

Preface	ix	(2)
Acknowledgments	xi
1 General Principles of Drug Action	1	(26)
I. Dose-response relationships	1	(3)
II. Drug absorption	4	(4)
III. Drug distribution	8	(2)
IV. Drug elimination and termination of action	10	(1)
V. Biotransformation (metabolism) of drugs	11	(3)
VI. Excretion of drugs	14	(2)
VII. Pharmacokinetics	16	(4)
Review test	20	(7)
2 Drugs Acting on the Autonomic Nervous System	27	(40)
I. The peripheral efferent nervous system	27	(5)
II. Parasympathomimetic drugs	32	(6)
III. Muscarinic-receptor antagonists	38	(2)
IV. Ganglionic-blocking drugs	40	(2)
V. Skeletal muscle relaxants	42	(5)
VI. Sympathomimetic drugs	47	(7)
VII. Adrenergic receptor antagonists	54	(7)
Review test	61	(6)
3 Drugs Acting on the Renal System	67	(14)
I. Diuretics	67	(7)
II. Nondiuretic inhibitors of tubular transport	74	(1)
III. Drugs that act on the renin-angiotensin system	75	(3)
Review test	78	(3)
4 Drugs Acting on the Cardiovascular System	81	(32)
I. Agents used to treat congestive heart failure (CHF)	81	(6)
II. Antiarrhythmic drugs	87	(6)
III. Antianginal agents	93	(3)
IV. Antihypertensive drugs	96	(8)
V. Drugs that lower plasma lipids	104	(5)
Review test	109	(4)
5 Drugs Acting on the Central Nervous System	113	(72)
I. Sedative-hypnotic drugs	113	(6)
II. Antipsychotic (neuroleptic) drugs	119	(6)
III. Antidepressant drugs	125	(7)
IV. Lithium	132	(1)
V. Opioid analgesics and antagonists	133	(10)
VI. Antiparkinsonian drugs	143	(4)
VII. Antiepileptic drugs	147	(5)
VIII. General anesthetics	152	(8)
IX. Local anesthetics	160	(5)
X. Drugs of abuse	165	(12)
Review test	177	(8)
6 Autacoids, Ergots, Anti-inflammatory Agents, and Immunosuppressive Agents	185	(32)
I. Histamine and antihistamines	185	(5)
II. Serotonin and serotonin antagonists	190	(3)
III. Ergots	193	(2)
IV. Kinins	195	(1)
V. Eicosanoids	196	(4)
VI. Nonsteroidal anti-inflammatory drugs (NSAIDs)	200	(8)
VII. Drugs used for gout	208	(1)
VIII. Immunosuppressive agents	209	(4)
Review test	213	(4)
7 Drugs Used in Anemia and Disorders of Hemostasis	217	(14)
I. Drugs used in the treatment of anemias	217	(4)
II. Drugs used in hemostatic disorders	221	(8)
Review test	229	(2)
8 Drugs Acting on the Gastrointestinal Tract	231	(18)
I. Emetics and antiemetics	231	(3)
II. Anorexigenics	234	(2)
III. Agents used for upper gastrointestinal tract disorders	236	(5)
IV. Pro-kinetic agents	241	(1)
V. Drugs used to dissolve gallstones	242	(1)
VI. Digestive enzyme replacements	243	(1)
VII. Agents that act on the lower gastrointestinal tract	243	(4)
Review test	247	(2)
9 Drugs Acting on the Pulmonary System	249	(14)
I. Introduction to pulmonary disorders	249	(1)
II. Agents used to treat asthma and other bronchial disorders	250	(6)
III. Drugs used to treat rhinitis and cough	256	(3)
Review test	259	(4)
10 Drugs Acting on the Endocrine System	263	(46)
I. Hormone receptors	263	(1)
II. The hypothalamus	263	(5)
III. The anterior pituitary	268	(3)
IV. The posterior pituitary	271	(2)
V. Drugs acting on the gonadal and reproductive system	273	(9)
VI. The adrenal cortex	282	(6)
VII. The thyroid	288	(3)
VIII. The pancreas and glucose homeostasis	291	(6)
IX. The calcium homeostatic system	297	(4)
X. Retinoic acid and derivatives	301	(2)
Review test	303	(6)
11 Drugs Used in Treatment of Infectious Diseases	309	(54)
I. Infectious disease therapy	309	(1)
II. Antibacterials	310	(22)
III. Antimycobacterial agents	332	(4)
IV. Antifungal agents	336	(4)
V. Antiparasitic drugs	340	(11)
VI. Antiviral drugs	351	(6)
Review test	357	(6)
12 Cancer Chemotherapy	363	(26)
I. Principles of cancer chemotherapy	363	(4)
II. Alkylating agents	367	(4)
III. Antimetabolites	371	(5)
IV. Natural products	376	(4)
V. Miscellaneous agents	380	(2)
VI. Steroid hormones and antagonists and related drugs	382	(3)
Review test	385	(4)
13 Toxicology	389	(20)
I. Principles and terminology	389	(2)
II. Air pollutants	391	(2)
III. Solvents	393	(1)
IV. Insecticides and herbicides	394	(2)
V. Fumigants and rodenticides	396	(1)
VI. Heavy metal poisoning and management	397	(6)
VII. Drug poisoning	403	(3)
Review test	406	(3)
Comprehensive Examination	409	(20)
Index	429