The Pharmacotherapy of Common Functional Syndromes

by Manu; Peter

• ISBN13: 9780789005892
• ISBN10: 0789005891
• Format: Nonspecific Binding
• Copyright: 2000-07-12
• Publisher: CRC Press

Summary

Get up-to-date with this invaluable guidebook! The four major functional disorders--chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and premenstrual syndrome--plague a sizable portion of humanity. In the past, they have been ignored, misdiagnosed, or treated with folk remedies (usually with less-than-optimum results), or inappropriate or ineffective medications. Now, The Pharmacotherapy of Common Functional Syndromes: Evidence-Based Guidelines for Primary Care Practice delivers a critical presentation of drug therapies for each of these disorders. This volume evaluates all of the best available research in this field to determine effective therapeutic approaches for these conditions. This thorough and lucid review discusses these four major functional disorders: chronic fatigue syndrome fibromyalgia irritable bowel syndrome premenstrual syndrome Here you can examine diagnostic criteria and treatment regimes that reveal what medicines and treatments had positive and negative responses for patients and the known risks and benefits of the drugs used in each case. This informative book gives medical professionals and their patients a concise and current source that contains the latest research on these topics. The Pharmacotherapy of Common Functional Syndromes: Evidence-Based Guidelines for Primary Care Practice is the single volume that will give you insight into each of these syndromes to help you decide what course of action to take with your patients and what medications are right for them.

Author Biography

Dr. Peter Manu is Director of Medical Services at Hillside Hospital, Long Island Jewish Medical Center, and Associate Professor at Albert Einstein College of Medicine.

Table of Contents

Introduction	1	(8)
SECTION I: CHRONIC FATIGUE SYNDROME
Definition and Methodological Issues	9	(4)
Controversial Treatments	13	(14)
Immunoglobulin Infusions	13	(8)
Hydrocortisone	21	(3)
Fish and Plant Oils	24	(3)
Ineffective Therapies	27	(6)
Fluoxetine	27	(6)
Unreplicated Trials	33	(22)
Phenelzine	33	(1)
Selegiline	34	(2)
Poly (I)-Poly (C12U)	36	(2)
Nicotinamide Adenine Dinucleotide	38	(2)
Magnesium	40	(2)
Acyclovir	42	(3)
Dialyzable Leukocyte Extract (Transfer Factor)	45	(2)
Alpha Interferon	47	(2)
Cyanocobalamin and Folic Acid	49	(1)
Terfenadine	50	(1)
Fludrocortisone	51	(4)
Evidence-Based Therapy of Chronic Fatigue Syndrome	55	(6)
SECTION II: FIBROMYALGIA
Definition and Methodological Issues	61	(2)
Effective Therapy	63	(12)
Tricyclic Antidepressants	63	(12)
Controversial Therapies	75	(18)
Cyclobenzaprine	75	(7)
Selective Serotonin Reuptake Inhibitors	82	(5)
S-Adenosylmethionine	87	(6)
Ineffective Drugs	93	(12)
Nonsteroidal Anti-Inflammatory Agents	93	(5)
Benzodiazepines	98	(2)
Nonbenzodiazepine Hypnotics	100	(5)
Unreplicated Trials	105	(12)
Ondansetron	105	(1)
Ritanserin	106	(1)
Prednisone	107	(2)
Chlormezanone	109	(1)
Growth Hormone	110	(2)
Calcitonin	112	(2)
Malic Acid and Magnesium	114	(3)
Evidence-Based Therapy of Fibromyalgia	117	(6)
SECTION III: IRRITABLE BOWEL SYNDROME
Definition and Methodological Issues	123	(2)
Effective Therapies	125	(6)
Tricyclic Antidepressants	125	(6)
Controversial Therapies	131	(22)
Bulking Agents	131	(5)
Smooth Muscle Relaxants	136	(8)
Calcium Channel Blocking Agents	144	(3)
Cisapride	147	(6)
Ineffective Therapies	153	(16)
Dietary Fiber	153	(6)
Lactase	159	(4)
Ondansetron	163	(6)
Unreplicated Trials	169	(6)
Streptococcus Faecium	169	(1)
Fedotozine	170	(2)
Chinese Herbal Medicine	172	(1)
Indian Herbal Medicine	173	(2)
Evidence-Based Therapy of Irritable Bowel Syndrome	175	(6)
SECTION IV: PREMENSTRUAL SYNDROME
Definition and Methodological Issues	181	(4)
Effective Therapy	185	(18)
Selective Serotonin Reuptake Inhibitors	185	(18)
Controversial Therapies	203	(26)
Gonadotropin-Releasing Hormone Agonists	203	(9)
Alprazolam	212	(7)
Bromocriptine	219	(4)
Danazol	223	(6)
Ineffective Therapies	229	(32)
Progesterone and Progestogens	229	(9)
Estrogens	238	(2)
Nonsteroidal Anti-Inflammatory Drugs	240	(3)
Beta-Adrenergic Blocking Agents	243	(3)
Spironolactone	246	(4)
Pyridoxine	250	(5)
Evening Primrose Oil	255	(3)
Magnesium	258	(3)
Unreplicated Trials	261	(8)
Calcium Carbonate	261	(3)
Alpha-Tocopherol	264	(1)
L-Tryptophan	265	(4)
Evidence-Based Therapy of Premenstrual Syndrome	269	(2)
Conclusions	271	(6)
References	277	(32)
Index	309