9780521199452

The Placenta and Human Developmental Programming

by
  • ISBN13:

    9780521199452

  • ISBN10:

    052119945X

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1/31/2011
  • Publisher: Cambridge University Press
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Summary

Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.

Table of Contents

Preface
Introduction
The maternal and placental origins of chronic disease David
Pre and periconceptual health and the HPA Axis: nutrition and stress
Nutrition and preimplantation development
Materno-fetal transport pathways during embryogenesis and organogenesis Eric Jauniaux
Imprinted genes and placental growth: implications for the developmental origins of health and disease
Genomic imprinting: epigenetic control and potential roles in the developmental origins of postnatal health and disease Elizabeth
Trophoblast invasion and uterine artery remodelling in primates Robert Pijnenborg, Lisbeth Vercruysse
The role of the maternal immune response in fetal programming
Clinical causes and aspects of placental insufficiency
Uterine blood flow as a determinant of feto-placental development
Placental amino acid transporters: the critical link between maternal nutrition and fetal programming? Thomas Jansson
The maternal circulation and placental shape: villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stress Graham
Glucocorticoids and placental programming
Clinical biomarkers of placental development
The placental roots of cardiovascular disease
Placental function and later risk of osteoporosis
The placenta and developmental programming: some reflections
Index
Table of Contents provided by Publisher. All Rights Reserved.

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