Platelet Function

by Quinn, Martin; Fitzgerald, Desmond

• ISBN13: 9781588292445
• ISBN10: 1588292444
• Format: Hardcover
• Copyright: 2005-07-21
• Publisher: Humana Pr Inc

Summary

A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.

Table of Contents

Preface	v
Contributors	ix
Part I. Platelet Physiology
Platelet Physiology	3	(18)
Martin Quinn
Platelet Integrins and Signaling	21	(22)
Karlheinz Peter
Platelet Adhesion	43	(28)
Brian Savage
Zaverio M. Ruggeri
Structure-Function of the Platelet Cytoskeleton	71	(44)
Elaine L. Bearer
Platelets and Inflammation	115	(34)
Meinrad Gawaz
Platelet Signal-Dependent Protein Synthesis	149	(26)
Stephan Lindemann
Thomas M. McIntyre
Stephen M. Prescott
Guy A. Zimmerman
Andrew S. Weyrich
Phosphoproteomics of Human Platelets	175	(26)
Katrin Marcus
Helmut E. Meyer
Part II. Assessing Platelet Function
Platelet Function Studies	201	(22)
Dermot Cox
Platelet Function Under Flow	223	(24)
Jose A. Lopez
Ian del Conde
Jing-Fei Dong
Pharmacodynamics of GPIIb-IIIa Receptor Blockade	247	(20)
Lisa K. Jennings
Melanie M. White
Prostanoid Generation in Platelet Function: Assessment and Clinical Relevance	267	(16)
Bianca Rocca
Carlo Patrono
Platelets and Prothrombin	283	(18)
Michael Kalafatis
Emil Negrescu
Tatiana Byzova
Edward F. Plow
Markers of Platelet Activation and Granule Secretion	301	(14)
Alan D. Michelson
Mark I. Furman
Genomic and Proteomic Analysis of Platelets: Clinical Applications	315	(20)
Andrew Maree
James McRedmond
Part III. Clinical Applications
Antiplatelet Agents	335	(34)
Jacqueline Saw
David J. Moliterno
Assessing Platelet Function in Clinical Trials	369	(16)
Neal Kleiman
Index	385